 | | Vol. 14.27 – 21 July, 2022 |
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| Researchers showed that the histone reader ZMYND8 was selectively expressed in breast cancer stem cells (BCSCs) and promoted epithelial-mesenchymal transition, BCSC maintenance and self-renewal, and oncogenic transformation through its epigenetic functions, leading to breast tumor initiation.
[Science Advances] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Using single-cell analysis of premenopausal breast tissue, investigators reveal a network of coordinated transcriptional programs representing the tissue-level response to changing hormone levels.
[Cell Systems] |
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| The authors reported that legumain (LGMN) was secreted in the zymogen form by motile breast cancer cells. The autocrine pro-LGMN activated FAK-Src-RhoA signaling in cancer cells and promoted cancer cell migration and invasion independent of LGMN protease activity.
[Oncogene] |
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| According to experimental results, significant up-regulation of circ_0041732 was confirmed in breast cancer tissues and cell lines. E2F4 was proved to transcriptionally modulate circ_0041732.
[Molecular Cancer Research] |
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| Researchers found that TAZ knockdown in two murine triple-negative breast cancer tumor cell line models significantly inhibited tumor growth and metastasis in immune competent but not immune deficient hosts.
[Cancer Gene Therapy] |
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| The single agent and radiosensitizing efficacy of KP167 and its parental comparator, AQ4N, were evaluated in 2D and 3D cultures of luminal and TNBC cell lines and compared against DNA damage repair inhibitors.
[Journal of Cellular and Molecular Medicine] |
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| Scientists investigated the effects of sirtuin 6 (SIRT6) on protein kinase C activator- and cytokine-mediated cancer cell invasion and migration in MCF-7 and MDA-MB-231 cells and the association between SIRT6 and matrix metalloproteinase-9 expression.
[Scientific Reports] |
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| Investigators explored the role and molecular mechanism of Twist1 in basal-like breast cancer.
[Translational Oncology] |
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| The anti-proliferative effects of two widely used statins were investigated on a panel of 15 cell lines representing the different molecular subtypes of breast cancer.
[Medical Oncology] |
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| Scientists offer a wide overview of autophagy’s underlying role in lung and breast cancer, particularly focusing on the various autophagy activators and inhibitors in both cancers, as well as the use of various organic compounds, regular drugs, and natural products in cancer prevention and treatment.
[Molecular Biology Reports] |
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| AstraZeneca and Daiichi Sankyo’s Enhertu has been approved in the European Union (EU) as a monotherapy for the treatment of adult patients with unresectable or metastatic HER2-positive breast cancer who have received one or more prior anti-HER2-based regimens.
[AstraZeneca PLC] |
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| Byondis B.V. announced that the European Medicines Agency (EMA) has validated the Marketing Authorization Application for the company’s investigational next generation anti-HER2 antibody-drug conjugate trastuzumab duocarmazine in patients with HER2-positive unresectable locally advanced or metastatic breast cancer.
[Byondis] |
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| October 20 – 21, 2022
Turin, Italy |
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| | Hershey College of Medicine – Hershey, Pennsylvania, United States |
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| | Catholic University of Louvain – Brussels, Belgium |
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| | Albert Einstein College of Medicine – Bronx, New York, United States |
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| | Memorial Sloan Kettering Cancer Center – New York, New York, United States |
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| | German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany |
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