 | | Vol. 14.32 – 1 September, 2022 |
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Scientists investigated whether cellular changes occurring in normal mammary tissues, prior to tumor initiation and in response to dysbiosis, enhanced dissemination of hormone receptor (HR)+ tumors.
[Cancer Immunology Research] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Mechanistically, Abelson (ABL) kinases phosphorylated the RNA-binding protein Y-box-binding protein 1 (YB-1). ABL kinase inhibition disrupted binding of YB-1 to the ERBB2 mRNA and impaired translation, leading to a profound decrease in HER2 protein levels.
[Cell Reports] |
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| Using a high-throughput imaging-based reporter drug screen with 9501 compounds, investigators identified three polo-like kinase 1 inhibitors as major inducers of estrogen receptor α protein expression and downstream activity in TNBC cells.
[Oncogene] |
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| Scientists found that knockdown of WDR5 in breast cancer cells independently impaired their tumorigenic as well as metastatic capabilities.
[eLife] |
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| Using proteomic analysis, the authors found intrinsic and acquired resistance mechanisms to proteolysis-targeting chimeras (PROTACs) in cancer cell lines mediated by greater abundance or production of the drug efflux pump MDR1.
[Science Signaling] |
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| Researchers found that the small-molecule tyrosine kinase inhibitor DCC-2036 suppressed TNBC stem cells by inhibiting the tyrosine kinase AXL and the transcription factor KLF5.
[Cell Death & Disease] |
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| Scientists demonstrated that GASP1 was highly expressed in breast cancers, and patients harboring altered GASP1 showed a worse prognosis than those with wild-type GASP1.
[Cell Death & Disease] |
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| Investigators found that the histological characteristics of organoids were consistent with original lesions and recapitulated their heterogenicity. In addition, the NGS results showed that PIK3CA and TP53 genes had detrimental mutations.
[Journal of Oncology] |
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| Researchers discuss the major mechanisms involved in the antitumorigenic functions of senescent cells, and then consider the cell-intrinsic and cell-extrinsic factors that participate in their switch towards a tumour-promoting role.
[Nature Reviews Clinical Oncology] |
| | The authors summarize the potential contribution of dysregulated ring finger (RNF) proteins, except for tripartite-motif family, to the pathogenesis of some diseases, including cancer, autoimmune diseases, and neurodegenerative disorder.
[Signal Transduction and Targeted Therapy] |
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| President Joe Biden’s administration announced that, by the end of 2025, federal agencies must make papers that describe taxpayer-funded work freely available to the public as soon as the final peer-reviewed manuscript is published.
[Science Insider] |
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| A complex mix of politics, economics and shifting career priorities has made it hard for principal investigators to recruit new lab members.
[Nature News] |
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| February 5 – 8, 2022
Keystone, Colorado, United States |
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| | STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada |
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| | Gunderson Health System – La Crosse, WI, United States |
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| | Michigan State University – East Lansing, Michigan, United States |
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| | The Institute of Cancer Research – London, UK |
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| | Dalhousie University – Halifax, Nova Scotia, Canada |
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Cancer Stem Cell News
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