ABL Kinases Regulate Translation in HER2⁺ Cells Through Y-Box-Binding Protein 1 to Facilitate Colonization of the Brain

Mechanistically, Abelson (ABL) kinases phosphorylated the RNA-binding protein Y-box-binding protein 1 (YB-1). ABL kinase inhibition disrupted binding of YB-1 to the ERBB2 mRNA and impaired translation, leading to a profound decrease in HER2 protein levels.