Investigators showed that BCL11A knockdown in TNBC cells delayed repair of oxidative DNA damage, increased the number of oxidized bases and abasic sites in genomic DNA, slowed down proliferation, and induced cellular senescence. [NAR Cancer]
Scientists demonstrated that the ASXL2 subunit of the BRCA1 associated protein-1 (BAP1) complex mediated a direct interaction with MLL3/COMPASS. ASXL2 loss results in decreased MLL3 occupancy at enhancers and reduced BAP1-MLL3 target gene expression. [Science Advances]
Researchers showed that systemic treatment with doxorubicin, but not cisplatin, following resection of a TNBC tumor induced the expression of complement factors in lung fibroblasts, and modulated an immunosuppressive metastatic niche that supported lung metastasis. [Nature Communications]
To determine which molecular alterations combined with loss of HOXA5 expression can transform cells, scientists examined isogenic derivatives of a nonmalignant breast epithelial cell line containing knock-in or knockout mutations in key breast cancer genes. [Cancer Research]
Researchers used a 4T1-Luc allograft BALB/c syngeneic mouse model and 4T1-Luc and MDA-MB-231 cells for histological analysis, qRT-PCR, western blotting, reactive oxygen species analysis, mammosphere formation analysis, and monolayer fluorescence imaging analysis. [Scientific Reports]
Thioridazine demonstrated the capability of destroying breast cancer stem cells and this effect was amplified when combined with carboplatin treatment. [Translational Oncology]
The authors review advances in the molecular endocrinology of mammary gland development and milk synthesis. They discuss the hormonal functions of the mammary gland, including parathyroid hormone-related peptide secretion that stimulates maternal calcium mobilization for milk synthesis. [Nature Reviews Endocrinology]
Due to Resveratrol’s (RES) promising potential as a chemopreventive and chemotherapeutic agent for breast cancer, this review aims to explore the anticancer mechanisms of RES using the most up to date research and addresses the effects of using nanomaterials as delivery systems. [Cellular and Molecular Life Sciences]
Jenny C Chang, MD, received a $250,000 grant to study the interaction between obesity and nitric oxide synthase in TNBC from the Cancer Prevention and Research Institute of Texas. [Houston Methodist (EurekAlert)]
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