Mesenchymal Cell News Volume 14.27 | Jul 12 2022

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    2022-07-12 | MESCN 14.27


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 14.27 – 12 July, 2022
    TOP STORY

    The Interplay of Collagen/Bioactive Glass Nanoparticle Coatings and Electrical Stimulation Regimes Distinctly Enhanced Osteogenic Differentiation of Human Mesenchymal Stem Cells

    Scientists introduced electric field (EF) with negligible magnetic field strength through a well-characterized transformer-like coupling system, and applied EF disrupted or consecutive regime on type I collagen coatings with/without bioactive glass nanoparticles over 28 days.
    [Acta Biomaterialia]

    AbstractGraphical Abstract
    Return to your lab safely and efficiently with these guides and resources so that you can focus more on moving your research goals forward.
    PUBLICATIONSRanked by the impact factor of the journal

    Tumor Suppressive Role of MicroRNA-139-5p in Bone Marrow Mesenchymal Stem Cells-Derived Extracellular Vesicles in Bladder Cancer through Regulation of the KIF3A/p21 Axis

    Bone Marrow MSCs-extracellular vesicles transferred miR-139-5p into bladder cancer cells where miR-139-5p inhibited the malignant features of bladder cancer cells in vitro.
    [Cell Death & Disease]

    Full Article

    Microarrayed Human Bone Marrow Organoids for Modeling Blood Stem Cell Dynamics

    Researchers built a 3D in vitro model system of bone marrow (BM) organoids that recapitulated several structural and cellular components of native BM.
    [APL Bioengineering]

    Full Article

    Enhancing Metabolic Activity and Differentiation Potential in Adipose Mesenchymal Stem Cells via High-Resolution Surface-Acoustic-Wave Contactless Patterning

    Investigators developed a standing surface acoustic wave-based platform and demonstrated its capability for the well-controlled and rapid cell patterning of adipose-derived MSCs in a high-density homogenous collagen hydrogel.
    [Microsystems & Nanoengineering]

    Full ArticleGraphical Abstract

    Patient-Specific Sarcoma Organoids for Personalized Translational Research: Unification of the Operating Room with Rare Cancer Research and Clinical Implications

    Surgically resected sarcomas were dissociated and incorporated into a hyaluronic acid and collagen-based extracellular matrix hydrogel and screened for chemotherapy efficacy.
    [Annals of Surgical Oncology]

    Abstract

    Conditioned Medium of Amniotic Fluid-Derived Stromal Cells Exerts a Bone Anabolic Effect by Enhancing Progenitor Population and Angiogenesis

    In an in vitro culture experiment, amniotic fluid-derived stromal cells increased osteoclast differentiation of bone marrow-derived macrophages, but had no significant effect on the osteogenic differentiation of preosteoblasts.
    [Journal of Tissue Engineering and Regenerative Medicine]

    Abstract

    Isolation and Identification of a Mesenchymal Stem/Stromal Cell-Like Population from Pediatric Urethral Tissue

    Researchers successfully isolated and cultured a population of mesenchymal stem-like cells from pediatric urethra.
    [In Vitro Cellular & Developmental Biology – Animal]

    Abstract

    Efficacy of HSV-TK/GCV System Suicide Gene Therapy Using Stem Cells from Human Exfoliated Deciduous Teeth Expressing Modified HSV-TK against Brain Metastasis of Non-Small-Cell Lung Cancer

    The authors described stem cells from human exfoliated deciduous teeth as gene vehicles of the thymidine kinase (TK)/ganciclovir (GCV) system against a brain metastasis model of non-small-cell lung cancer.
    [Molecular Therapy-Methods & Clinical Development]

    AbstractFull ArticleGraphical Abstract

    Gingiva-Derived Mesenchymal Stem Cells Attenuate Imiquimod- (IMQ-) Induced Murine Psoriasis-Like Skin Inflammation

    Investigators isolated and characterized gingiva-derived MSCs (GMSCs) in 2D and 3D culture conditions and found that GMSCs in 2D and 3D infusion could significantly ameliorate the imiquimod-induced murine psoriasis-like skin inflammation.
    [Stem Cells International]

    Full Article

    Therapeutic Effect of Adipose-Derived Mesenchymal Stem Cells (AD-MSCs) Compared to Pirfenidone on Corticosteroid Resistance in a Mouse Model of Acute Exacerbation of Idiopathic Pulmonary Fibrosis

    Researchers assessed the therapeutic effects of AD-MSCs on corticosteroid resistance in an animal model of acute exacerbation-idiopathic pulmonary fibrosis caused by bleomycin compared to pirfenidone.
    [Histology and Histopathology]

    Abstract

    Survey results on the needs and challenges in the human pluripotent stem cell field
    REVIEWS

    Mesenchymal Stem Cell–Derived Extracellular Vesicles as an Advanced Therapy for Chronic Wounds

    The authors review the evidence demonstrating that MSC-extracellular vesicles target the processes leading to chronic wounds.
    [Cold Spring Harbor Perspectives in Biology]

    Abstract

    INDUSTRY AND POLICY NEWS

    Stem Cell and Skin Regeneration: Hamilton Health Sciences Creates World-Class Burn Treatment Program

    One of Ontario’s only two burn centers is developing a world-class program to provide specialized treatment in the Hamilton-Niagara region and beyond.
    [In The Hammer]

    Press Release

    FEATURED EVENT

    Danish Stem Cell Society (DASCS) 2022

    September 19 – 20, 2022
    Vejle, Denmark

    > See All Events

    JOB OPPORTUNITIES

    Associate Professor – Thematic Research Programs

    The Chinese University of Hong Kong – Hong Kong, China

    Postdoctoral Researcher – Cartilage Regeneration

    University Medical Center Utrecht – Utrecht, Netherlands

    Postdoctoral Position – Sarcoma Pathology

    The University of Iowa – Iowa City, Iowa, United States

    PhD Scholarship – Enhancers Communities

    University of Southern Denmark – Odense M, Denmark

    Postdoctoral Researcher – Immunomodulation

    National University of Ireland Galway – Galway, Ireland

    > See All Jobs

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