Mesenchymal Cell News Volume 14.33 | Aug 23 2022

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    2022-08-23 | MESCN 14.33


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 14.33 – 23 August, 2022
    TOP STORY

    AIF1+CSF1R+ MSCs, Induced by TNF-α, Act to Generate an Inflammatory Microenvironment and Promote Hepatocarcinogenesis

    Using single-cell RNA sequencing, we identified a distinct inflammation-associated subset of MSCs, namely AIF1+CSF1R+ MSCs, which existed in the microenvironment before the occurrence of liver cancer.
    [Hepatology]

    Full Article
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    PUBLICATIONSRanked by the impact factor of the journal

    Mesenchymal Stromal Cells Improve the Transplantation Outcome of CRISPR-Cas9 Gene-Edited Human HSPCs

    Researchers developed a mesenchymal stromal cell-based co-culture system to optimize transplantation outcome of CRISPR-Cas9 gene-edited human hematopoietic stem and progenitor cells.
    [Molecular Therapy]

    AbstractFull ArticleGraphical Abstract

    Microfluidic Evidence of Synergistic Effects between Mesenchymal Stromal Cell-Derived Biochemical Factors and Biomechanical Forces to Control Endothelial Cell Function

    Scientists used two different microfluidic designs to investigate critical steps during angiogenesis and found pronounced effects of endothelial cell proliferation as well as chemotactic and mechanotactic migration induced by bone marrow MSCs conditioned medium.
    [Acta Biomaterialia]

    AbstractGraphical Abstract

    Potential of Stem Cell Seeded Three-Dimensional Scaffold for Regeneration of Full-Thickness Skin Wounds

    Investigators conducted skin regeneration in a rat model of full-thickness dermal wound by transplanting genetically modified MSCs seeded on a 3D collagen scaffold.
    [Journal of the Royal Society interface]

    Full Article

    Development of a Mouse Salivary Gland-Derived Mesenchymal Cell Line for Immunological Studies of Murine Cytomegalovirus

    The authors reported a BALB/c-derived mouse salivary gland cell line immortalized using the SV40 large T antigen. Cells stained positive for PDGFR1 and negative for E-cadherin and PECAM-1, indicating mesenchymal origin.
    [PLoS One]

    Full Article

    m6A-Related lncRNAs Predict Overall Survival of Patients and Regulate the Tumor Immune Microenvironment in Osteosarcoma

    The Cancer Genome Atlas database was used to retrieve RNA sequencing and medical information from osteosarcoma sufferers.
    [Computational intelligence and Neuroscience]

    Full Article

    The Effects of Placental Mesenchymal Stem Cells Labeled with Ultrasmall Superparamagnetic Iron Oxides on the Growth of Colorectal Cancer Cells

    Mice injected with labeled placental mesenchymal stem cells were considered as the experimental group. The growth and MR signal changes of xenograft tumors of every nude mouse were measured.
    [Journal of Computer Assisted Tomography]

    Full Article

    Human Gingival Mesenchymal Stem Cells Improve Movement Disorders and Tyrosine Hydroxylase Neuronal Damage in Parkinson Disease Rats

    RNA sequencing and quantitative proteomics technology was used to validate the neuroprotective role of gingival MSCs therapeutic in 6-Hydroxydopamine -induced Parkinson disease model in vitro and in vivo.
    [Cytotherapy]

    Abstract

    Integrin β1, PDGFRβ, and Type II Collagen Are Essential for Meniscus Regeneration by Synovial Mesenchymal Stem Cells in Rats

    Rat synovial MSCs were treated with neutralizing antibodies for integrin β1, PDGFRβ, or CD44 or with the CRISPR/Cas9 system to delete Vcam1, Tnfr1, or Col2a1 genes.
    [Scientific Reports]

    Full Article
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    REVIEWS

    Synovial Joint-on-a-Chip for Modeling Arthritis: Progress, Pitfalls, and Potential

    The authors review major steps in the generation of organ-on-chip (OoC) for studying arthritis, discuss the challenges faced when these novel platforms enter the next phase of development and application, and present the potential for OoC technology to investigate the pathogenesis of joint diseases.
    [Trends in Biotechnology]

    Abstract

    20 Years with SGBS Cells – a Versatile In Vitro Model of Human Adipocyte Biology

    Investigators provide an update on the characterization of SGBS cells, present basic methods for their application and summarize results of a systematic literature search on original data obtained with this cell strain.
    [International Journal of Obesity]

    Full Article
    INDUSTRY AND POLICY NEWS

    Amniotics Phase I/II Study of PulmoStem™ in Hospitalized COVID-19 Patients Ready to Start

    Amniotics AB announced that several batches of PulmoStem™ have been certified by the company’s Qualified Person and that clinical sites in the UK and Sweden are set to start the enrollment of subjects in the first-in-human Phase I/II study of hospitalized COVID-19 patients.
    [Amniotics AB]

    Press Release
    FEATURED EVENT

    The Matrix in Development

    September 12 – 14, 2022
    Liverpool, England, United Kingdom

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    JOB OPPORTUNITIES

    Associate Director – Management of PSC Biology

    STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada

    Postdoctoral Position – Vascular Biology Lab

    University of Turin – Torino, Italy

    Assistant Member – Genes and Human Disease Research Program

    Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States

    Faculty Member – Faculty of Life and Health Sciences

    Shenzhen Institute of Advanced Technology – Shenzhen, China

    Postdoctoral Researcher – Regenerative Medicine

    National University of Ireland Galway – Galway, Ireland

    > See All Jobs

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