| Vol. 14.33 – 23 August, 2022 |
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| Using single-cell RNA sequencing, we identified a distinct inflammation-associated subset of MSCs, namely AIF1+CSF1R+ MSCs, which existed in the microenvironment before the occurrence of liver cancer. [Hepatology] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers developed a mesenchymal stromal cell-based co-culture system to optimize transplantation outcome of CRISPR-Cas9 gene-edited human hematopoietic stem and progenitor cells. [Molecular Therapy] |
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| Scientists used two different microfluidic designs to investigate critical steps during angiogenesis and found pronounced effects of endothelial cell proliferation as well as chemotactic and mechanotactic migration induced by bone marrow MSCs conditioned medium. [Acta Biomaterialia] |
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| Investigators conducted skin regeneration in a rat model of full-thickness dermal wound by transplanting genetically modified MSCs seeded on a 3D collagen scaffold. [Journal of the Royal Society interface] |
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| The authors reported a BALB/c-derived mouse salivary gland cell line immortalized using the SV40 large T antigen. Cells stained positive for PDGFR1 and negative for E-cadherin and PECAM-1, indicating mesenchymal origin. [PLoS One] |
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| The Cancer Genome Atlas database was used to retrieve RNA sequencing and medical information from osteosarcoma sufferers. [Computational intelligence and Neuroscience] |
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| Mice injected with labeled placental mesenchymal stem cells were considered as the experimental group. The growth and MR signal changes of xenograft tumors of every nude mouse were measured. [Journal of Computer Assisted Tomography] |
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| RNA sequencing and quantitative proteomics technology was used to validate the neuroprotective role of gingival MSCs therapeutic in 6-Hydroxydopamine -induced Parkinson disease model in vitro and in vivo. [Cytotherapy] |
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| Rat synovial MSCs were treated with neutralizing antibodies for integrin β1, PDGFRβ, or CD44 or with the CRISPR/Cas9 system to delete Vcam1, Tnfr1, or Col2a1 genes. [Scientific Reports] |
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| The authors review major steps in the generation of organ-on-chip (OoC) for studying arthritis, discuss the challenges faced when these novel platforms enter the next phase of development and application, and present the potential for OoC technology to investigate the pathogenesis of joint diseases. [Trends in Biotechnology] |
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| Investigators provide an update on the characterization of SGBS cells, present basic methods for their application and summarize results of a systematic literature search on original data obtained with this cell strain. [International Journal of Obesity] |
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| Amniotics AB announced that several batches of PulmoStem™ have been certified by the company’s Qualified Person and that clinical sites in the UK and Sweden are set to start the enrollment of subjects in the first-in-human Phase I/II study of hospitalized COVID-19 patients. [Amniotics AB] |
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| September 12 – 14, 2022 Liverpool, England, United Kingdom |
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| STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada |
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| University of Turin – Torino, Italy |
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| Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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| Shenzhen Institute of Advanced Technology – Shenzhen, China |
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| National University of Ireland Galway – Galway, Ireland |
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