Synovial Joint-on-a-Chip for Modeling Arthritis: Progress, Pitfalls, and Potential

The authors review major steps in the generation of organ-on-chip (OoC) for studying arthritis, discuss the challenges faced when these novel platforms enter the next phase of development and application, and present the potential for OoC technology to investigate the pathogenesis of joint diseases and the development of efficacious therapies.