 | | Vol. 14.34 – 30 August, 2022 |
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| Scientists investigated the role of LIN28a in cartilage physiology and in osteoarthritis (OA). Lin28a-inducible conditional cartilage deletion up-regulated Mmp13 in intact mice and exacerbated the cartilage destruction in OA mice.
[Science Advances] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The activation of mTOR could promote cell entry into S phase, thereby enhancing DNA synthesis and cell proliferation.
[Bone Research] |
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| An autocrine loop was postulated where the neoplastic cells would be stimulated through CSF1R expressed on their surface. The authors used single-cell RNA sequencing to investigate cellular interactions in tenosynovial giant cell tumor.
[Clinical Cancer Research] |
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| Researchers investigated the molecular mechanism underlying the association between cyclin-dependent protein kinase 7 (CDK7) and glucose-regulated protein 78-kDa (GRP78) in osteosarcoma.
[Oncogene] |
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| The authors explored the role and molecular mechanisms of quercetin on the protective effect of bone marrow-derived MSCs under oxidative stress in vitro.
[Journal of Molecular Endocrinology] |
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| Investigators evaluated miR-659-3p and SRPK1 function in osteosarcoma cell proliferation, migration, and cell cycle progression in vitro by using gain- and loss-of-function strategies.
[BMC Cancer] |
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| Scientists fabricated polyacrylamide hydrogels with gradient stiffness to unravel the role of matrix stiffness in chondrogenic process of MSCs, with or without TGF-β3 as induction factor.
[Journal of Molecular Histology] |
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| Researchers described the embryonic origin of appendicular Hic1+ mesenchymal progenitors and demonstrated that they arose in the hypaxial somite, and migrated into the developing limb at embryonic day 11.5, well after limb bud initiation.
[Nature Communications] |
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| Investigators demonstrated a strong correlation between TANK-binding kinase 1 (TBK1) and osteoarthritis (OA), evidenced by the significantly downregulated expression of TBK1 in cartilage tissue samples of OA patients and in the chondrocytes of aged mice.
[Acta Pharmacologica Sinica] |
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| The best source of MSCs seems to be the umbilical cord due to the easiness of extraction, the noninvasive method of collection, their higher expansion ability, and more powerful immune-modulating properties compared to other locations in the body.
[Regenerative Therapy] |
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| Longeveron, Inc. announced that the European Patent Office has issued a notice of its intent to grant the company a patent related to methods to treat endothelial dysfunction and monitor the efficacy of allogeneic mesenchymal cell therapies, also known as medicinal signaling cells.
[Longeveron, Inc.] |
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| November 10 – 12, 2022
Bordeaux, France |
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| | STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada |
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| | German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany |
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| | STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada |
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| | University of Turin – Torino, Italy |
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| | Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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