TBK1-Medicated DRP1 Phosphorylation Orchestrates Mitochondrial Dynamics and Autophagy Activation in Osteoarthritis

Investigators demonstrated a strong correlation between TBK1 and osteoarthritis (OA), evidenced by significantly downregulated expression of TBK1 in cartilage tissue samples of OA patients and in the chondrocytes of aged mice, as well as TNF-α-stimulated phosphorylation of TBK1 in primary mouse chondrocytes.