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JAGGED-NOTCH3 Signaling in Vascular Remodeling in Pulmonary Arterial Hypertension | The NOTCH ligand DELTA-LIKE 4 was minimally expressed in small pulmonary artery smooth muscle cells from individuals with pulmonary arterial hypertension, inhibited NOTCH3 cleavage and signaling, and retarded vascular smooth muscle cell proliferation.
[Science Translational Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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Targeting McOln1/TRPML1 Channels to Protect against Ischemia-Reperfusion Injury by Restoring the Inhibited Autophagic Flux in Cardiomyocytes | Researchers discovered that the MCOLN1-mediated inhibition of autophagy induced byischemia-reperfusion impaired mitochondrial function, which resulted in further detrimental reactive oxygen speciesrelease that directly contributed to cardiomyocyte death.
[Autophagy] |
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Stage-Specific Regulation of Signaling Pathways to Differentiate Pluripotent Stem Cells to Cardiomyocytes with Ventricular Lineage | Differentiation of embryonic bodies resulted in early fetal like non-contractile ventricular cardiomyocytes with an inherent propensity to contract when stimulated.
[Stem Cell Research & Therapy] |
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A Biosensing System Using a Multiparameter Nonlinear Dynamic Analysis of Cardiomyocyte Beating for Drug-Induced Arrhythmia Recognition | The biosensing system cultured cardiomyocytes as physiologically relevant models, used interdigitated electrodes to detect the mechanical beating of the cardiomyocytes, and employed multiparameter nonlinear dynamic algorithm analysis to recognize drug-induced arrhythmia from the cardiomyocyte beating recording.
[Microsystems & Nanoengineering] |
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Irisin Protects Cardiomyocytes against Hypoxia/Reoxygenation Injury via Attenuating AMPK Mediated Endoplasmic Reticulum Stress | Irisin could efficiently protect cardiomyocytes from hypoxia/reoxygenation-injury via attenuating endoplasmic reticulum (ER) stress and ER stress-induced apoptosis.
[Scientific Reports] |
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Disheveled Binding Antagonist of β-Catenin 1 Interacted with β-Catenin and Connexin 43 in Human-Induced Pluripotent Stem Cells-Derived Cardiomyocytes | Investigators used cardiomyocytes derived from human embryonic stem cells and induced pluripotent stem cells to investigate the role of disheveled binding antagonist of β-catenin 1 and its connection with β-catenin and connexin 43.
[Bioengineered] |
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| AR Cooperates with SMAD4 to Maintain Skeletal Muscle Homeostasis | The authors found that the presence of an elongated polyQ tract impaired androgen receptor (AR) cooperativity with mothers against decapentaplegic homolog (SMAD4), leading to an inability to mount an effective anti-atrophy gene expression programme in skeletal muscle in response to denervation.
[Acta Neuropathologica] |
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Peroxynitrous Acid-Modified Extracellular Matrix Alters Gene and Protein Expression in Human Coronary Artery Smooth Muscle Cells and Induces a Pro-inflammatory Phenotype | Scientists hypothesized that extracellular matrix modification by peroxynitrite/peroxynitrous acid might drive smooth muscle cells undergoing a phenotypic switch from quiescent/contractile to proliferative/synthetic, and thereby potentially contribute to atherogenesis.
[Free Radical Biology and Medicine] |
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Vascular Smooth Muscle Cell C-fos Is Critical for Foam Cell Formation and Atherosclerosis | Researchers investigated whether c-Fos played a role in hyperlipidemia-induced vascular smooth muscle cell-derived foam cell formation and atherosclerosis.
[Metabolism-Clinical and Experimental] |
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Acute Elution of TGFβ2 Affects the Smooth Muscle Cells in a Compliance-Matched Vascular Graft | The authors suggested that transforming growth factor beta 2 (TGFβ2) could modulate in vivo smooth muscle cell phenotype over an acute implantation period,
[Tissue Engineering Part A] |
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MiR-320a Targeting RGS5 Aggravates Atherosclerosis by Promoting Migration and Proliferation of Ox-LDL-Stimulated Vascular Smooth Muscle Cells | MiR-320a promoted cell viability, migration, and proliferation while reducing apoptosis of oxidized low-density lipoproteins (ox-LDL)-stimulated vascular smooth muscle cells by inhibiting RGS5.
[Journal of Cardiovascular Pharmacology] |
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The Cell-Autonomous and Non–Cell-Autonomous Roles of the Hippo Pathway in Heart Regeneration | The authors summarize recent studies that highlight how the Hippo pathway regulates heart regeneration through cell-autonomous and non–cell-autonomous mechanisms.
[Journal of Molecular and Cellular Cardiology] |
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Natural Products: Potential Therapeutic Agents to Prevent Skeletal Muscle Atrophy | Scientists summarize various experimental and clinical evidence of some important bioactive compounds that shall help in the development of novel strategies to counteract skeletal muscle atrophy elicited by various causes.
[European Journal of Pharmacology] |
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LianBio Completes Phase I Pharmacokinetic Study of Mavacamten in Healthy Chinese Volunteers | LianBio announced the completion of a Phase I pharmacokinetic study of mavacamten in healthy Chinese volunteers. The study was conducted in parallel to an ongoing Phase III clinical trial of mavacamten in Chinese patients with symptomatic obstructive hypertrophic cardiomyopathy.
[LianBio (GlobeNewswire, Inc.)] |
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| September 13 – 14, 2022
London, UK |
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| | Dayton, Ohio, United States – Wright State University |
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| | Duke University – Durham, North Carolina, United States |
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| | Shiok Meats Pte Ltd – Singapore, Singapore |
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| | Harvard University – Cambridge, Massachusetts, United States |
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| | University of California, San Diego – La Jolla, California, United States |
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