Targeting McOln1/TRPML1 Channels to Protect against Ischemia-Reperfusion Injury by Restoring the Inhibited Autophagic Flux in Cardiomyocytes

Researchers discovered that the MCOLN1-mediated inhibition of autophagy induced byischemia-reperfusion impaired mitochondrial function, which resulted in further detrimental reactive oxygen speciesrelease that directly contributed to cardiomyocyte death.