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Influenza Virus Replication in Cardiomyocytes Drives Heart Dysfunction and Fibrosis | To test the etiology of this aspect of influenza disease, scientists generated a novel recombinant heart-attenuated influenza virus via genome incorporation of target sequences for miRNAs expressed in cardiomyocytes.
[Science Advances] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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HDAC6 Modulates Myofibril Stiffness and Diastolic Function of the Heart | Histone deacetylase 6 (HDAC6) overexpression in cardiomyocytes led to decreased myofibril stiffness, as did ex vivo treatment of mouse, rat, and human myofibrils with recombinant HDAC6.
[Journal of Clinical Investigation] |
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Protective Mechanisms of 10-Gingerol against Myocardial Ischemia May Involve Activation of JAK2/STAT3 Pathway and Regulation of Ca2+ Homeostasis | The authors investigated the protection conferred by 10-Gingerol against myocardial ischemia injury and its potential mechanisms in cardiomyocytes via patch-clamp and molecular biology techniques.
[Biomedicine & Pharmacotherapy] |
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A Possible New Activator of PI3K-Huayu Qutan Recipe Alleviates Mitochondrial Apoptosis in Obesity Rats with Acute Myocardial Infarction | Researchers evaluated effect of Huayu Qutan Recipe pretreatment on myocardial apoptosis induced by acute myocardial infarction by regulating mitochondrial function via PI3K/Akt/Bad pathway in rats with obesity.
[Journal of Cellular and Molecular Medicine] |
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TECRL Deficiency Results in Aberrant Mitochondrial Function in Cardiomyocytes | Using loss- and gain-of-function approaches, the authors investigated the role of TECRL in murine and human cardiomyocytes.
[Communications Biology] |
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Effects of NRF-1 and PGC-1α Cooperation on HIF-1α and Rat Cardiomyocyte Apoptosis under Hypoxia | Investigators established a myocardial hypoxia model and investigated the effects of these proteins on the proliferation and apoptosis of rat cardiomyocytes under hypoxia.
[Gene] |
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The Regulatory Mechanism and Effect of RIPK3 on PE-induced Cardiomyocyte Hypertrophy | Primary cardiomyocytes were pretreated with receptor-interacting protein kinase 3 (RIPK3) inhibitor GSK’872, and RIPK3 siRNA was used to deplete the intracellular expression of RIPK3.
[Journal of Cardiovascular Pharmacology] |
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| Marsupsin Isolated from Polyherbal Product ABPA Rejuvenates Insulin Resistance in L6 Skeletal Muscle Cell Line via IRS1-PI3K-AKT-GLUT4 Signaling Pathway | Marsupsin rejuvenated insulin resistance in skeletal muscle cells by increasing the rate of glucose uptake through the activation of the IRS1-PI3K-AKT-GLUT4 pathway.
[FASEB Journal] |
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Effects of Arbutin on Glucose Uptake by Glucose Transporter 4 (GLUT4) and Its Cytoprotective Properties in L6 Skeletal Muscle Cell Line | Researchers evaluated arbutin’s effects on glucose uptake by GLUT4 and cytoprotective properties in the L6 skeletal muscle cell line.
[Cell Biochemistry and Function] |
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Diminished Rbfox1 Increases Vascular Constriction by Dynamically Regulating Alternative Splicing of CaV1.2 Calcium Channel in Hypertension | By whole-cell patch clamp, investigators identified knockdown of Rbfox1 induced the hyperpolarization of CaV1.2 current-voltage relationship curve in vascular smooth muscle cells.
[Clinical Science] |
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Interactions between β3-Adrenergic Receptors and bFGF-Induced Effects in Rat Aortic Smooth Muscle Cells | Scientists explored the possible role of β3-adrenergic receptors in vascular injury-induced neointima formation by testing its effects on basic fibroblast growth factor (bFGF)-induced vascular smooth muscle cell migration and proliferation.
[FASEB Journal] |
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Linear Ubiquitination Modification of NR6A1 by LUBAC Inhibits RIPK3 Kinase Activity and Attenuates Apoptosis of Vascular Smooth Muscle Cells | LUBAC-induced linear ubiquitination of nuclear receptor subfamily 6 group A member 1 (NR6A1) could potentially arrest the apoptosis of vascular smooth muscle cells in atherosclerosis by downregulating receptor-interacting serine/threonine-protein kinase 3 and attenuating caspase activity.
[Journal of Biochemical and Molecular Toxicology] |
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Targeting Adipokines: A New Strategy for the Treatment of Myocardial Fibrosis | The authors provide new ideas for targeting adipokines in the treatment of myocardial fibrosis and provide strategies for the development of new, safe, and effective pharmacological antagonists against myocardial fibrosis based on adipokines activity.
[Pharmacological Research] |
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Faraday Pharmaceuticals Announces First Patient Enrolled in Phase III Trial for Myocardial InfarctionIocyte AMI-3 Trial | Faraday Pharmaceuticals, Inc., announced the enrollment of the first patient in its Iocyte AMI-3 study — a Phase III clinical trial assessing the efficacy and safety of FDY-5301 in reducing cardiovascular death and heart failure in anterior ST-segment elevation myocardial infarction patients undergoing primary percutaneous intervention.
[Faraday Pharmaceuticals, Inc. (BioSpace)] |
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| December 10 – 14, 2022
Maui, Hawaii, United States |
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| | Shenzhen Institute of Advanced Technology Chinese Academy of Sciences – Shenzhen, Guangdong, China |
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| | Dayton, Ohio, United States – Wright State University |
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| Duke University – Durham, North Carolina, United States |
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| | Shiok Meats Pte Ltd – Singapore, Singapore |
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| | Harvard University – Cambridge, Massachusetts, United States |
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