NewslettersMuscle Cell News HDAC6 Modulates Myofibril Stiffness and Diastolic Function of the Heart By Ishira - May 16, 2022 0 92 Histone deacetylase 6 (HDAC6) overexpression in cardiomyocytes led to decreased myofibril stiffness, as did ex vivo treatment of mouse, rat, and human myofibrils with recombinant HDAC6. [Journal of Clinical Investigation] Full ArticlePress ReleaseGraphical Abstract