HDAC6 Modulates Myofibril Stiffness and Diastolic Function of the Heart

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Histone deacetylase 6 (HDAC6) overexpression in cardiomyocytes led to decreased myofibril stiffness, as did ex vivo treatment of mouse, rat, and human myofibrils with recombinant HDAC6.
[Journal of Clinical Investigation]
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