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| Machinery was faithfully validated in de novo pacemaker cardiomyocytes (PCs) of adult mice and rats, and in human PCs derived from induced pluripotent stem cells.
[Circulation Research] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers examined the effects of relaxin on sphingosine 1-phosphate, and the potential benefits of relaxin treatment on cardiac health in a rodent model of ischemic heart failure.
[Scientific Reports] |
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| Lysosome-associated membrane protein 2a verexpression and knockdown were used to causally study chaperone-mediated autophagy’s role in hypoxically-stressed cardiomyocytes.
[American Journal of Physiology-Cell Physiology] |
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| Scientists demonstrated that satellite cells initiated expression of the myogenic transcription factor MyoD, which then induced re-expression of fetal genes in the myofibers that destabilized the sarcolemma.
[Nature Communications] |
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| The authors genetically reduced the expression of mechanosensors integrin-linked kinase and kindlin-2 in myogenic C2C12 cells and analyzed the gene expression of mechanosensors, clock components and metabolism-controlling genes.
[Cellular and Molecular Life Sciences] |
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| Investigators examined dishevelled (DVL) function in human myogenesis and the muscle-related cancer alveolar rhabdomyosarcoma.
[Scientific Reports] |
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| A selenium (Se)-deficient skeletal muscle model was established. The skeletal muscle tissue and blood Se content were significantly reduced in the Se deficiency group.
[Biological Trace Element Research] |
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| Scientists demonstrated a role for KCNJ8/ABCC9-containing ATP-sensitive potassium channel (K-ATP) channels in the differentiation of brain vascular smooth muscle cell, which in turn was necessary for fine-tuning of cerebral blood flow.
[Developmental Cell] |
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| Researchers specifically deleted androgen receptor in smooth muscle cells of the adult mouse prostate under two tumorigenic conditions, namely, the Hi-Myc genetic model and the T + E2 hormonal carcinogenesis model.
[Cell Reports] |
| | The focal adhesion kinase (FAK) gene expression levels and phosphorylated FAK protein values were evaluated in vascular smooth muscle cells treated with different doses of metformin, based on cell viability using quantitative reverse transcription PCR, western blotting and methyl thiazol tetrazolium techniques.
[Endocrinology, Diabetes & Metabolism] |
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| Cardiovascular gene therapy research has focused on determining the safety and efficacy of rare alternative serotypes and/or genetically engineered adenoviral capsid protein-modified vectors following local or systemic delivery.
[Journal of Molecular Medicine] |
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| SOLVE FSHD announced its’ financial support to the FSHD Canada Foundation’s strategic investment of US$1.2M in biomarker grant funding to facilitate biomarker research in facioscapulohumeral muscular dystrophy (FSHD).
[SOLVE FSHD] |
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| October 3 – 5
Vancouver, British Columbia, Canada |
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| | Utrecht University – Utrecht, Netherlands |
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| | Shenzhen Institute of Advanced Technology Chinese Academy of Sciences – Shenzhen, Guangdong, China |
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| | Dayton, Ohio, United States – Wright State University |
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| Duke University – Durham, North Carolina, United States |
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