Muscle Cell News Volume 7.20 | Jun 13 2022

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    2022-06-013 | MSUCN 7.20


    Muscle Cell News by STEMCELL Technologies
    Vol. 7.20 – 20 June, 2022
    TOP STORY

    Epigenetic Reactivation of Transcriptional Programs Orchestrating Fetal Lung Development in Human Pulmonary Hypertension

    Silencing of TBX4, TBX5, SOX9, or E1A-associated protein P300 by RNA interference or small-molecule compounds regressed PAH phenotypes and mesenchymal signatures in arterial FBs and smooth muscle cells.
    [Science Translational Medicine]

    Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    Active Force Generation Contributes to the Complexity of Spontaneous Activity and to the Response to Stretch of Murine Cardiomyocyte Cultures

    Using stretchable microelectrode arrays, we assessed the effects of the myosin inhibitor blebbistatin and the nonselective stretch-activated channel blocker streptomycin on beating variability and on the response of neonatal or fetal murine ventricular cell cultures against deformation.
    [Journal of Physiology-London]

    Abstract

    Circular RNA Circ-RCCD Promotes Cardiomyocyte Differentiation in Mouse Embryo Development via Recruiting YY1 to the Promoter of MyD88

    Functional experiments revealed that inhibition of circ-RCCD dramatically suppressed the formation of beating cell clusters, the fluorescence intensity of cardiac differentiation marker MF20, and the expression of the myocardial-specific markers CTnT, Mef2c, and GATA4.
    [Journal of Cellular and Molecular Medicine]

    Full Article

    The Mechanism of the Imbalance Between Proliferation and Ferroptosis in Pulmonary Artery Smooth Muscle Cells Based on the Activation of SLC7A11

    SLC7A11 was up-regulated in Sugen5416/hypoxia-induced pulmonary arterial hypertension (PAH) rats and patients with PAH. Moreover, solute carrier family 7 member 11 (SLC7A11) inhibited ferroptosis and promoted proliferation by overexpressing SLC7A11 in pulmonary artery smooth muscle cells.
    [European Journal of Pharmacology]

    Abstract

    Antioxidant Effects of Bis-Indole Alkaloid Indigo and Related Signaling Pathways in the Experimental Model of Duchenne Muscular Dystrophy

    Investigators evaluated the potential role of the indigo on oxidative stress and related signaling pathways in primary skeletal muscle cell cultures and in the diaphragm muscle from mdx mice.
    [Cell Stress & Chaperones]

    Abstract

    PPARγ Activation Inhibits PDGF-Induced Pulmonary Artery Smooth Muscle Cell Proliferation and Migration by Modulating TERT

    The authors explored whether telomerase reverse transcriptase mediates the proliferation and migration of pulmonary arterial smooth muscle cells and the underlying molecular mechanism.
    [Biomedicine & Pharmacotherapy]

    Full ArticleGraphical Abstract

    Rosmarinic Acid Inhibits Platelet Aggregation and Neointimal Hyperplasia In Vivo and Vascular Smooth Muscle Cell Dedifferentiation, Proliferation, and Migration In Vitro via Activation of the Keap1-Nrf2-ARE Antioxidant System

    Researchers investigated the effects of rosmarinic acidon platelet function, vascular smooth muscle cells phenotypic conversion, proliferation, and migration in vascular remodeling with a specific focus on the Keap1-Nrf2-ARE signaling pathway.
    [Journal of Agricultural and Food Chemistry]

    AbstractGraphical Abstract

    Activation of the GTPase ARF6 Regulates Invasion of Human Vascular Smooth Muscle Cells by Stimulating MMP14 Activity

    The authors defined whether platelet-derived growth factor, a mitogenic stimulant of vascular tissues, and Angiotensin II, a potent vasoactive peptide, could result in the activation of adenosine diphosphate ribosylation factor 6 (ARF6) in a human model of aortic smooth muscle cell.
    [Scientific Reports]

    Full Article

    Salvianolic Acid A From Danhong Injection Induces Vasorelaxation by Regulating L-Type Calcium Channel in Isolated Mouse Arteries

    Scientists determined the vasodilating substances of Danhong injection and explained its molecular mechanism of vasodilation. With molecular biology experiments, it was verified that the relevant mechanisms were closely related to calcium-mediated vasoconstriction in smooth muscle cells.
    [Journal of Ethnopharmacology]

    Abstract

    Cysteine and Glycine-Rich Protein 2 Promotes Hypoxic Pulmonary Vascular Smooth Muscle Cell Proliferation Through the Wnt3α-β-Catenin/Lymphoid Enhancer-Binding Factor 1 Pathway

    Investigators discovered that cysteine and glycine-rich protein 2 (Csrp2) expression was increased both in pulmonary arteries and smooth muscle cells in pulmonary hypertension.
    [Journal of Biochemical and Molecular Toxicology]

    Abstract

    Circular RNA circ_0021001 Regulates miR-148b-3p/GREM1 Axis To Modulate Proliferation and Apoptosis of Vascular Smooth Muscle Cells

    The binding relationship between miR-148b-3p and circ_0021001 or gremlin 1 (GREM1) was predicted by StarBase and then verified using a dual-luciferase reporter assay.
    [Metabolic Brain Disease]

    Abstract
    Request your free copy of the 'Directed Differentiation of Pluripotent Stem Cells' Wallchart
    REVIEWS

    Electrical Stimulation Through Conductive Scaffolds for Cardiomyocyte Tissue Engineering: Systematic Review and Narrative Synthesis

    Scientists ask how has the application of external electrical stimulation in conductive scaffolds for tissue engineering affected cardiomyocyte behavior in in vitro cell culture?
    [Annals of the New York Academy of Sciences]

    Full Article
    INDUSTRY AND POLICY NEWS

    FibroGen Announces Completion of Patient Enrollment in LELANTOS-2, a Phase III Clinical Study of Pamrevlumab in Duchenne Muscular Dystrophy

    FibroGen, Inc. announced completion of patient enrollment for LELANTOS-2, a Phase III clinical study of pamrevlumab in patients with ambulatory Duchenne muscular dystrophy.
    [FibroGen, Inc.]

    Press Release
    FEATURED EVENT

    EASL NAFLD Summit 2022

    September 15 – September 17
    Dublin, Ireland, United Kingdom

    > See All Events

    JOB OPPORTUNITIES

    Scientific Director – Electrophysiology and Heart Modeling

    Electrophysiology and Heart Modeling Institute – Bordeaux, France

    PhD Candidate – Cellular and Molecular Mechanisms of Cancer

    Norwegian University of Science and Technology -Trondheim, Norway

    Research Analyst – Biofabrication

    Utrecht University – Utrecht, Netherlands

    Principal Investigator – Interdisciplinary Research in Biology

    CNRS – Paris, France

    Postdoctoral Fellow – Heart and Muscle Disease Modeling and Regeneration

    Duke University – Durham, North Carolina, United States

    > See All Jobs

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