Activation of the GTPase ARF6 Regulates Invasion of Human Vascular Smooth Muscle Cells by Stimulating MMP14 Activity

The authors defined whether platelet-derived growth factor, a mitogenic stimulant of vascular tissues, and Angiotensin II, a potent vasoactive peptide, could result in the activation of adenosine diphosphate ribosylation factor 6 (ARF6) in a human model of aortic smooth muscle cell.