Muscle Cell News Volume 7.22 | Jun 27 2022

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    2022-06-27 | MUSCN 7.22


    Muscle Cell News by STEMCELL Technologies
    Vol. 7.22 – 27 June, 2022
    TOP STORY

    A Carbon-Based Biosensing Platform for Simultaneously Measuring the Contraction and Electrophysiology of iPSC-Cardiomyocyte Monolayers

    Researchers developed a biosensing platform that was capable of performing on-chip and simultaneous measurement of contractility and electrophysiology of human induced pluripotent stem-cell-derived (iPSC) cardiomyocyte monolayers.
    [ACS Nano]

    AbstractGraphical Abstract
    Explore tools and resources for your return to the lab
    PUBLICATIONSRanked by the impact factor of the journal

    RhoA Signaling Increases Mitophagy and Protects Cardiomyocytes Against Ischemia by Stabilizing PINK1 Protein and Recruiting Parkin to Mitochondria

    The authors showed that signaling through RhoA, a small GTPase, induced mitophagy via modulation of the PTEN-induced kinase 1 (PINK1)/Parkin pathway as a protective mechanism against ischemic stress.
    [Cell Death & Differentiation]

    Full Article

    miR-107 Attenuates Sepsis-Induced Myocardial Injury by Targeting PTEN and Activating the PI3K/AKT Signaling Pathway

    Scientists investigated the mechanism of miR-107 on sepsis-induced myocardial injury. Sepsis rat models were established by cecal ligation and puncture, and the cell model was established using lipopolysaccharide-induced cardiomyocytes.
    [Cells Tissues Organs]

    Abstract

    A Case of Congenital Fiber-Type Disproportion Syndrome Presenting Dilated Cardiomyopathy With ACTA1 Mutation

    Investigators performed exome sequencing and analyzed the effect of Met327Lys mutations on cultured C2C12 muscle cells compared with that seen in the wild type (ACTA1) and previously identified Asp294Val mutations associated with a severe phenotype of congenital fiber-type disproportion without cardiomyopathy.
    [Molecular Genetics & Genomic Medicine]

    Full Article

    Elevated miR-145-5p Is Associated with Skeletal Muscle Dysfunction and Triggers Apoptotic Cell Death in C2C12 Myotubes

    A novel miR-145-5p was significantly upregulated in the serum collected from patients with chronic obstructive pulmonary disease-associated muscle atrophy, in contrast with the normal participants.
    [Journal of Muscle Research and Cell Motility]

    Abstract

    Global O-GlcNAcylation Changes Impact Desmin Phosphorylation and Its Partition Toward Cytoskeleton in C2C12 Skeletal Muscle Cells Differentiated Into Myotubes

    In a model of C2C12 myotubes, researchers modulated the global O-GlcNAcylation level, and they determined whether the expression, the post-translational modifications and the partition of desmin toward insoluble material or cytoskeleton were impacted or not.
    [Scientific Reports]

    Full Article

    Identification of ER/SR Resident Proteins as Biomarkers for ER/SR Calcium Depletion in Skeletal Muscle Cells

    Researchers examined the exodosis profile of skeletal muscle cells following endoplasmic/sarcoplasmic reticulum (ER/SR) calcium depletion.
    [Orphanet Journal of Rare Diseases]

    Full Article

    Efficacy and Limitations of Senolysis in Atherosclerosis

    Scientists examined the specificity of senescence markers in vascular smooth muscle cells and the effects of genetic or pharmacological senolysis in atherosclerosis.
    [Cardiovascular Research]

    Full Article
    Graphical Abstract

    Dichotomous Roles of Smooth Muscle Cell–Derived MCP1 (Monocyte Chemoattractant Protein 1) in Development of Atherosclerosis

    The authors investigated the contribution of inflammatory MCP1 produced by both classical myosin heavy chain 11+ smooth muscle cells (SMCs) and SMCs that have transitioned through a galectin 3+ state in atherosclerosis.
    [Arteriosclerosis Thrombosis and Vascular Biology]

    Abstract

    Soluble Epoxide Hydrolase Inhibitor, TPPU, Attenuates Progression of Atherosclerotic Lesions and Vascular Smooth Muscle Cell Phenotypic Switching

    Researchers investigated the therapeutic effect of TPPU on atherosclerosis in vivo and homocysteine-induced vascular inflammation in vitro and explored their molecular mechanisms.
    [Vascular Pharmacology]

    AbstractGraphical Abstract

    miR-564: A Potential Regulator of Vascular Smooth Muscle Cells and Therapeutic Target for Aortic Dissection

    By using quantitative real-time PCR and fluorescence in situ hybridization, scientists detected the expression levels of miR-564 in vitro and in vivo.
    [Journal of Molecular and Cellular Cardiology]

    Full ArticleGraphical Abstract
    How to prioritize and manage your research projects
    REVIEWS

    Modeling the Human Heart Ex Vivo—Current Possibilities and Strive for Future Applications

    The authors describe existing examples of heart muscle either in vitro or ex vivo models and discussed potential options for the further development of such structures.
    [Journal of Tissue Engineering and Regenerative Medicine]

    Full Article
    INDUSTRY AND POLICY NEWS

    Astellas’ Gene Therapy Strategy Faces Fresh Setback as FDA Puts Pompe Disease Med on Hold

    Astellas’ gene therapy ambitions have faced yet another setback. The FDA has slammed the breaks on a Phase I/II study of the Japanese pharma’s Pompe disease med while the regulator investigates a report of nerve damage in one of the trial’s participants.
    [Fierce Biotech]

    Full Article
    FEATURED EVENT

    Danish Stem Cell Society (DASCS) 2022

    September 19 – 20 2022
    Vejle, Denmark

    > See All Events

    JOB OPPORTUNITIES

    Animal Surgery – Cardiac and Skeletal Muscle Disease

    Duke University – Durham, North Carolina, United States

    Postdoctoral Researcher – Stem Cells and Regenerative Medicine

    Aarhus University – Aarhus C, Denmark

    Postdoctoral Fellow – Interorgan Crosstalk

    Washington University School of Medicine – St. Louis, Missouri, United States

    Postdoctoral Scientist – Cardiovascular Systems

    University of California, San Diego – La Jolla, California, United States

    Scientific Director – Electrophysiology and Heart Modeling

    Electrophysiology and Heart Modeling Institute – Bordeaux, France

    > See All Jobs

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