Muscle Cell News Volume 7.23 | Jul 4 2022

July 4, 2022

2022-07-04 | MUSCN 7.23

Muscle Cell News by STEMCELL Technologies

Vol. 7.23 – 4 July, 2022

TOP STORY

Prolonged Cardiac NR4A2 Activation Causes Dilated Cardiomyopathy in Mice

Scientists interrogated the consequences of cardiac nuclear receptor subfamily 4 group A member 2 (NR4A2) up-regulation under normal conditions and in response to pressure overload.
[Basic Research in Cardiology]

Full Article

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PUBLICATIONSRanked by the impact factor of the journal

CARDIAC MUSCLE CELLS

SNTA1 Gene Rescues Ion Channel Function and Is Antiarrhythmic in Cardiomyocytes Derived From Induced Pluripotent Stem Cells From Muscular Dystrophy Patients

To test whether dystrophin mutations led to defective cardiac NaV1.5–Kir2.1 channelosomes and arrhythmias, the authors generated induced pluripotent stem cell cardiomyocytes from two hemizygous Duchenne Muscular Dystrophy males, a heterozygous female, and two unrelated control males.
[eLife]

Full Article

UCP2 Modulates Cardiomyocyte Cell Cycle Activity, Acetyl-CoA and Histone Acetylation in Response to Moderate Hypoxia

Investigators determineed whether mitochondrial UCP2 was a metabolic oxygen sensor regulating cardiomyocyte cell cycle.
[JCI Insight]

Abstract Graphical Abstract

SKELETAL MUSCLE CELLS

Large-Scale Genome Editing Based on High-Capacity Adenovectors and CRISPR-Cas9 Nucleases Rescues Full-Length Dystrophin Synthesis in DMD Muscle Cells

Fully viral gene-deleted adenovector particles were investigated as sources of optimized high-specificity CRISPR-Cas9 nucleases and donor DNA constructs tailored for targeted insertion of full-length dystrophin expression units.
[Nucleic Acids Research]

Full Article
Graphical Abstract

Combined Fibre Atrophy and Decreased Muscle Regeneration Capacity Driven by Mitochondrial DNA Alterations Underlie the Development of Sarcopenia

Scientists expressed a dominant-negative variant of the mitochondrial helicase, which induced mtDNA alterations, specifically in differentiated myofibres, and muscle stem cells, respectively.
[Journal of Cachexia Sarcopenia and Muscle]

Full Article

Enhanced Myogenesis by Silencing Myostatin with Nonviral Delivery of dCas9 Ribonucleoprotein Complex

Investigators determined the CRISPR interference-mediated gene silencing effect of the nonviral delivery of nuclease-deactivated dCas9 ribonucleoprotein complex on muscle regeneration at the cellular and molecular level.
[CRISPR Journal]

Abstract

SMOOTH MUSCLE CELLS

Single Cell Transcriptomics Reveals Dynamic Role of Smooth Muscle Cells and Enrichment of Immune Cell Subsets in Human Abdominal Aortic Aneurysms

The authors provided the first comprehensive evaluation of single cell composition of the abdominal aortic wall and revealed how the gene expression landscape is altered in human abdominal aortic aneurysms.
[Annals of Surgery]

Abstract

Mitochondrial Transfer Regulates Bioenergetics in Healthy and COPD Airway Smooth Muscle

Researchers showed that airway smooth muscle cells from both healthy ex-smoker and chronic obstructive pulmonary disease subjects could exchange mitochondria, a process that happens, at least partly, via extracellular vesicles.
[American Journal of Respiratory Cell and Molecular Biology]

Abstract

Galectin-3 Induces Vascular Smooth Muscle Cells Calcification via AMPK/TXNIP Pathway

Investigators evaluated the role of TXNIP in galectin-3-induced vascular calcification. A primary culture of mouse vascular smooth muscle cells was established by enzymatic digestion of aorta.
[Aging-Us]

Full Article

Apatinib Through Activating the RhoA/ROCK Signaling Pathway to Cause Dysfunction of Vascular Smooth Muscle Cells

Scientists observed that apatinib caused dysfunction of mouse vascular smooth muscle cells cells through the RhoA/ROCK signaling pathway and Y27632, a nonspecific ROCK inhibitor.
[Applied Biochemistry and Biotechnology]

Abstract

REVIEWS

Modeling the Human Heart Ex Vivo—Current Possibilities and Strive for Future Applications

The authors describe existing examples of heart muscle either in vitro or ex vivo models and discussed potential options for the further development of such structures.
[Journal of Tissue Engineering and Regenerative Medicine]

Full Article

The Insulin Receptor Family in the Heart: New Light on Old Insights

Scientists review important aspects of the effects of the three insulin receptor family members in the heart.
[Bioscience Reports]

Abstract

Direct Mechanisms of SARS-CoV-2-Induced Cardiomyocyte Damage: An Update

Investigators shed light on the direct injury caused by SARS-CoV-2 to provide a comprehensive understanding of the cardiac manifestations of coronavirus disease 2019.
[Virology Journal]

Full Article

INDUSTRY AND POLICY NEWS

XyloCor Therapeutics Achieves Target Enrollment in Phase II EXACT Study of XC001 Novel Gene Therapy for Ischemic Heart Disease

XyloCor Therapeutics, announced it has achieved enrollment of target number of subjects in the Phase II portion of its ongoing Phase I/II clinical trial for refractory angina.
[XyloCor Therapeutics (Business Wire, Inc.)]

Press Release

FEATURED EVENT

Muscle Cell News Volume 7.23 | Jul 4 2022

Prolonged Cardiac NR4A2 Activation Causes Dilated Cardiomyopathy in Mice

SNTA1 Gene Rescues Ion Channel Function and Is Antiarrhythmic in Cardiomyocytes Derived From Induced Pluripotent Stem Cells From Muscular Dystrophy Patients

UCP2 Modulates Cardiomyocyte Cell Cycle Activity, Acetyl-CoA and Histone Acetylation in Response to Moderate Hypoxia

Large-Scale Genome Editing Based on High-Capacity Adenovectors and CRISPR-Cas9 Nucleases Rescues Full-Length Dystrophin Synthesis in DMD Muscle Cells

Combined Fibre Atrophy and Decreased Muscle Regeneration Capacity Driven by Mitochondrial DNA Alterations Underlie the Development of Sarcopenia

Enhanced Myogenesis by Silencing Myostatin with Nonviral Delivery of dCas9 Ribonucleoprotein Complex

Single Cell Transcriptomics Reveals Dynamic Role of Smooth Muscle Cells and Enrichment of Immune Cell Subsets in Human Abdominal Aortic Aneurysms

Mitochondrial Transfer Regulates Bioenergetics in Healthy and COPD Airway Smooth Muscle

Galectin-3 Induces Vascular Smooth Muscle Cells Calcification via AMPK/TXNIP Pathway

Apatinib Through Activating the RhoA/ROCK Signaling Pathway to Cause Dysfunction of Vascular Smooth Muscle Cells

Modeling the Human Heart Ex Vivo—Current Possibilities and Strive for Future Applications

The Insulin Receptor Family in the Heart: New Light on Old Insights

Direct Mechanisms of SARS-CoV-2-Induced Cardiomyocyte Damage: An Update

XyloCor Therapeutics Achieves Target Enrollment in Phase II EXACT Study of XC001 Novel Gene Therapy for Ischemic Heart Disease

i-Vaccines 2021: International Vaccines & Virology Conference

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Associate Professor – Cardiovascular Research

Animal Surgery – Cardiac and Skeletal Muscle Disease

Postdoctoral Researcher – Stem Cells and Regenerative Medicine

Postdoctoral Fellow – Interorgan Crosstalk

Postdoctoral Scientist – Cardiovascular Systems

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