SNTA1 Gene Rescues Ion Channel Function and Is Antiarrhythmic in Cardiomyocytes Derived From Induced Pluripotent Stem Cells From Muscular Dystrophy Patients

To test whether dystrophin mutations led to defective cardiac NaV1.5–Kir2.1 channelosomes and arrhythmias, scientists generated induced pluripotent stem cell cardiomyocytes from two hemizygous Duchenne Muscular Dystrophy males, a heterozygous female, and two unrelated control males.