 | | Vol. 7.26 – 25 July, 2022 |
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| Scientists demonstrated that SIRT6 deacetylated H3K56ac in myofibers to suppress expression of utrophin, a dystrophin-related protein stabilizing the sarcolemma in absence of dystrophin.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers discovered the pivotal long non-coding RNAs in myocardial ischemia/reperfusion injury.
[Communications Biology] |
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| The authors investigated the functions and mechanism of m6A methyltransferase METTL3 for septic myocardial injury.
[Cell Death Discovery] |
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| Scientists investigated the biocompatibility of an elastomeric electrospun degradable polar/hydrophobic/ionic polyurethane composite scaffold with human-induced pluripotent stem cell-derived cardiomyocytes.
[Journal of Biomedical Materials Research Part A] |
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| Researchers investigated whether heat shock protein 70 (HSP70) played an anti-apoptotic role in H9C2 cardiomyocytes by regulating the calcium overload pathway through stromal interaction molecule 1 and inositol 1,4,5-triphosphate receptor (STIM1/IP3R).
[Cell Stress & Chaperones] |
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| The authors established a realistic workflow for the production of cultured meat that mimiced the pork meat structurally and was potentially scalable for industry.
[Biomaterials] |
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| Investigators identified Pax7 Associated Muscle lncRNA (PAM), that was induced in activated/proliferating muscle satellite cells (SCs) upon injury to promote SC proliferation as myoblast cells.
[Aging Cell] |
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| Scientists characterized the expression and functional relevance of L-Type amino acid transporter 1 during different stages of myogenesis and in response to growth and atrophic conditions in vitro.
[American Journal of Physiology-Cell Physiology] |
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| Researchers demonstrated that PC2 was a central protein in mediating both the intracellular calcium ion responses and mitochondrial changes seen in myogenesis. they created CRISPR/Cas9 knockout C2C12 murine myoblast cell lines.
[American Journal of Physiology-Cell Physiology] |
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| Investigators studied the effect of uridine-5′-monophosphate (5′-CMP) and cytidine-5′-monophosphate (5′-UMP) on muscular differentiation and mitochondrial biogenesis in myoblast C2C12 cells.
[Biochemistry and Biophysics Reports] |
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| The authors investigated the role of NF-κB signaling in smooth muscle cells (SMCs) in atherosclerosis by employing SMC-specific ablation of NEMO, an IKK complex subunit that is essential for canonical NF-κB activation, in ApoE−/− mice.
[Scientific Reports] |
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| Researchers examined whether KIR2.1 altered pulmonary artery smooth muscle cell proliferation and migration, and participated in pulmonary vascular remodeling, as well as explored its mechanisms of action.
[International Journal of Molecular Medicine] |
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| 2D monolayer culturing and the 3D in vitro systems of cardiac spheroids, organoids, engineered cardiac microtissue and bioprinting are introduced with their basic concepts, advantages, and limitations.
[European Journal of Heart Failure] |
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| Capricor Therapeutics announced commencement of dosing in HOPE-3, a Phase III clinical trial investigating CAP-1002, a cell therapy for treating late-stage Duchenne muscular dystrophy
[Capricor Therapeutics] |
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| October 24 – 26, 2022
Madrid, Spain |
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| | Ohio State University Wexner Medical Center – Columbus, Ohio, United States |
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| | Cincinnati Children’s Hospital Medical Center – Cincinnati, Ohio, United States |
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| | Sarepta Therapeutics, Inc. – Columbus, Ohio, United States |
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| | Ohio State University Wexner Medical Center – Columbus, Ohio, United States |
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| | The Chinese University of Hong Kong – Hong Kong, China |
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