Smooth Muscle Cell Specific NEMO Deficiency Inhibits Atherosclerosis in ApoE^−/− Mice

Researchers investigated the role of NF-κB signaling in smooth muscle cells (SMCs) in atherosclerosis by employing SMC-specific ablation of NEMO, an IKK complex subunit that is essential for canonical NF-κB activation, in ApoE^−/− mice.