 | | Vol. 7.28 – 15 August, 2022 |
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| HHEX cooperated with the pioneer transcription factors (TFs) FOXA1, FOXA2 and GATA4, shared by both pancreas and liver differentiation programmes, to promote pancreas commitment, and this cooperation restrained the shared TFs from activating alternative lineages.
[Nature Cell Biology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators presented a method whereby maturation of human induced pluripotent stem cells-CMs could be accelerated by simultaneous application of physiological Ca2+ and frequency-ramped electrical pacing in culture.
[Stem Cell Reports] |
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| To improve the maturity and physiological relevance of hiPSC-derived cardiomyocytes, scientists co-cultured them with preconstructed vascular-like networks to form a functional, human cell-based cardiac tissue model.
[Scientific Reports] |
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| Researchers investigated the role of exosomal miRNA-133 secreted by cardiac fibroblasts in promoting cardiomyocyte differentiation.
[Acta Histochemica] |
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| The authors established understandings on the effects of graphene nanoplatelets matrices on muscle regeneration and inhibition of fat formation in vitro and the ability of GnP matrices to reverse muscle degenerative changes in vivo following an massive rotator cuff tears.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Using global Panx1 knockout mice, scientists demonstrated that Panx1 loss reduced muscle fiber size and strength, decreased satellite cell (SC) number, and altered early SC differentiation and myoblast fusion in male, but not in female mice.
[Journal of Cellular Physiology] |
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| The authors reported the acute effects of sodium nitrite on the bioenergetic behaviour of cultured rat myocytes.
[PLoS One] |
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| The silencing of Akt1 in vascular smooth muscle cells led to the downregulation of angiopoietin 1 and the upregulation of angiopoietin 2.
[Experimental and Molecular Medicine] |
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| Scientists investigated the effect of thoracic perivascular adipose tissue (T-PVAT) transplantation on aortic aneurysm formation and the impact of T-PVAT on vascular smooth muscle cells.
[Acta Pharmacologica Sinica] |
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| The authors showed that apolipoprotein A5 had a protective effect in pulmonary vessels and evaluated the mechanism.
[Lipids in Health and Disease] |
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| Researchers investigated the function of miR-182-5p in vascular smooth muscle cells phenotypic switch.
[Cell Biology International] |
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| The authors review on the relatively less well studied effects of G protein-coupled receptors (GPCRs) in cardiac fibroblasts, focusing on key signalling events involved in the activation and differentiation of these cells.
[American Journal of Physiology-Cell Physiology] |
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| Aro Biotherapeutics announced that the FDA granted Orphan Drug Designation for ABX1100, an investigational Centyrin-siRNA conjugate that targets the Gys1 gene in the muscle, for the treatment of Pompe disease.
[Aro Biotherapeutics] |
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| LianBio announced the completion of enrollment in the Phase III EXPLORER-CN clinical study of mavacamten in Chinese patients with symptomatic obstructive hypertrophic cardiomyopathy.
[LianBio] |
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| October 17 – 20, 2022
Palermo, Italy |
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| | Duke University – Durham, North Carolina, United States |
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| | University of Alberta – Edmonton, Alberta, Canada |
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| | Yale University – New Haven, Connecticut, United States |
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| | Nationwide Children’s Hospital – Columbus, Ohio, United States |
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| | Gilead Sciences, Inc. – Foster City, California, United States |
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