Muscle Cell News Volume 7.33 | Sep 26 2022

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    Jamie Kang
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    2022-09-26 | MUSCN 7.33


    Muscle Cell News by STEMCELL Technologies
    Vol. 7.33 – 26 September, 2022
    TOP STORY

    lncRNA-Smad7 Mediates Cross-Talk between Nodal/TGF-β and BMP Signaling to Regulate Cell Fate Determination of Pluripotent and Multipotent Cells

    Investigators showed that Nodal-induced lncRNA-Smad7 regulated cell fate determination via repression of BMP signaling in mouse embryonic stem cells by inducing myogenesis and cardiomyocyte differentiation.
    [Nucleic Acids Research]

    Full Article
    Request your free copy of the 'Directed Differentiation of Pluripotent Stem Cells' Wallchart
    PUBLICATIONSRanked by the impact factor of the journal

    Coupled Myovascular Expansion Directs Cardiac Growth and Regeneration

    Researchers profiled proliferation kinetics of cardiac endothelial cells and cardiomyocytes in neonatal mouse hearts and found they are spatiotemporally coupled, revealing a myovascular niche that may be therapeutically targeted for heart regeneration.
    [Development]

    Abstract

    Hereditary E200K Mutation within the Prion Protein Gene Alters Human iPSC Derived Cardiomyocyte Function

    Scientists differentiated cardiomyocyte cultures from donor human induced pluripotent stem cells (iPSCs) and found a direct influence of the PRNP E200K mutation on cellular function.
    [Scientific Reports]

    Full Article

    Multiscale Engineered Human Skeletal Muscles with Perfusable Vasculature and Microvascular Network Recapitulating the Fluid Compartments

    Researchers demonstrated a construction model for contractile engineered human skeletal muscle tissues with large vasculatures and networks to be utilized for potential drug testing platforms.
    [Biofabrication]

    Abstract

    Stretching Muscle Cells Induces Transcriptional and Splicing Transitions and Changes in SR Proteins

    Investigators studied how stretching skeletal muscle cells impacted global alternative splicing and gene expression programs using deep RNA-sequencing at two different stages of myogenesis.
    [Communications Biology]

    Full Article

    Single Nuclei Transcriptomics of Muscle Reveals Intra-Muscular Cell Dynamics Linked to Dystrophin Loss and Rescue

    Scientists isolated individual nuclei from minute quantities of frozen skeletal muscle from healthy and Duchenne muscular dystrophy patients to explore cellular and transcriptomic mechanisms of dystrophin loss and repair within an intact muscle environment.
    [Communications Biology]

    Full Article

    P-TAK1 Acts as a Switch between Myoblast Proliferation Phase and Differentiation Phase in Mdx Mice via Regulating HO-1 Expression

    Researchers utilized C2C12 cells to inhibit transforming growth factor-β-activated kinase 1 (TAK1) phosphorylation and markedly suppressed the expression of heme oxygenase-1. They found both myoblast proliferation and differentiation were inhibited.
    [European Journal of Pharmacology]

    AbstractGraphical Abstract

    Immunoglobulin A Promotes IL-6 and IL-8 Production, Proliferation, and Migration by the Human Bronchial Smooth Muscle Cells

    Scientists investigated the effects of Immunoglobulin A on the human bronchial smooth muscle cell, which played a major role in airway inflammation and remodeling through enhanced cell proliferation and migration.
    [Cellular Immunology]

    Abstract

    Exploring the Difference in the Mechanics of Vascular Smooth Muscle Cells from Wild Type and Apolipoprotein-E Knockout Mice

    Using an atherosclerotic murine model, researchers analyzed how the mechanics of vascular smooth muscle cells isolated from western diet fed apolipoprotein-E knockout and wild-type mice were altered during atherosclerosis.
    [American Journal of Physiology-Cell Physiology]

    Abstract
    Dr. Kristina McBurney and Leanna Bedell discuss how you can use social media to advance your scientific career. Watch now.
    REVIEWS

    Protective Effect of Natural Medicinal Plants on Cardiomyocyte Injury in Heart Failure: Targeting the Dysregulation of Mitochondrial Homeostasis and Mitophagy

    Investigators cover the relevant mechanisms of different types of mitophagy in regulating heart failure pathology and controlling mitochondrial adaptability to stress injury.
    [Oxidative Medicine and Cellular Longevity]

    Full Article

    Emerging Roles of Ferroptosis in Cardiovascular Diseases

    The authors summarize the characteristics and related mechanisms of ferroptosis and focus on its role in cardiovascular diseases, with the goal of inspiring novel treatment strategies.
    [Cell Death Discovery]

    Full Article
    INDUSTRY AND POLICY NEWS

    Immunis Initiates Patient Enrollment for Muscle Atrophy Phase I/IIa Clinical Trial

    Immunis, Inc. initiated patient enrollment for their Phase I/IIa clinical trial to assess Immunis’ immunomodulatory secretome product, IMM01-STEM, in patients with muscle atrophy.
    [Immunis, Inc.]

    Press Release
    FEATURED EVENT

    Heart Development and Disease: From Genes to Cures

    February 12 – 15, 2023
    Santa Fe, New Mexico, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Diabetes Complications and Metabolism

    City of Hope – Duarte, California, United States

    Postdoctoral Position – Stem Cell Organoids

    Syracuse University – Syracuse, New York, United States

    Postdoctoral Fellows – Molecular Metabolism

    University of Gothenburg – Gothenburg, Sweden

    Research Associate – Skeletal Muscle Disease

    UC San Diego Health – San Diego, California, United States

    Postdoctoral Research Associate – Rhabdomyosarcoma

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

    > See All Jobs

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