P-TAK1 Acts as a Switch between Myoblast Proliferation Phase and Differentiation Phase in Mdx Mice via Regulating HO-1 Expression

Researchers utilized C2C12 cells to inhibit transforming growth factor-β-activated kinase 1 (TAK1) phosphorylation and markedly suppressed the expression of heme oxygenase-1. They found both myoblast proliferation and differentiation were inhibited.