 | | Vol. 7.41 – 5 December, 2022 |
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| Scientists demonstrated the importance of HMGCS2-induced ketogenesis as a means to regulate metabolic response to cardiomyocyte injury, thus allowing cell dedifferentiation and proliferation as a regenerative response.
[Circulation] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors presented a soft resistive force-sensing diaphragm based on ultrasensitive resistive nano-cracked platinum film, which could be integrated into an all-soft culture well via an oxygen plasma-enabled bonding process.
[Nature Communications] |
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| Researchers demonstrated that glucocorticoid receptor signaling activated by dexamethasone pretreatment prior to doxorubicin exposure preserved cardiomyocyte viability and contractility in cardiomyocytes containing the rs28714259 allele.
[Nature Communications] |
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| Investigators examined the effects of vitamin D deficiency and supplementation on whole-body energy expenditure and muscle mitochondrial function in old rats, old mice, and human subjects.
[Communications Biology] |
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| The impact of Huntingtin (HTT) deficiency was studied in human skeletal muscle cell lines and in a mouse model with inducible and muscle-specific HTT deletion.
[Journal of General Physiology] |
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| Scientists determined to what extent PCM1 was a specific marker of myonuclei in vitro and in vivo.
[American Journal of Physiology-Cell Physiology] |
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| To determine the mechanisms of aortic medial amyloid formation, investigators explored the impact of vascular smooth muscle cell senescence, extracellular vesicle secretion, and extracellular matrix remodeling on medin accumulation.
[Aging Cell] |
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| Researchers generated proof that plasma-derived exosomes confer pulmonary hypertension by delivering lipoprotein receptor-1 (LOX-1) into pulmonary artery smooth muscle cells.
[Biochemical Pharmacology] |
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| Scientists temporally controlled Notch activation to promote arteriovenous fistula maturation while avoiding neointima formation.
[Journal of Translational Medicine] |
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| Investigators focus on phenotypic characteristics, molecular profile, the functional role of vascular smooth muscle cells (VSMCs) phenotype landscape, and the molecular mechanism regulating VSMCs phenotype switching.
[Cell Communication and Signaling] |
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| Researchers highlight important mechanisms that occur in the hearts of baby mice and zebrafish, which may help contribute to their regenerative abilities.
[Regenerative Medicine] |
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| Sarepta Therapeutics, Inc. announced that the US FDA had accepted the company’s Biologics License Application seeking accelerated approval of SRP-9001 for the treatment of ambulant individuals with Duchenne muscular dystrophy.
[Sarepta Therapeutics, Inc.] |
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| January 24 – 26, 2023
Boston, Massachusetts, United States |
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| | University of Stirling – Stirling, Scotland, United Kingdom |
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| | University of British Columbia – Vancouver, British Columbia, Canada |
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| | Erasmus University Medical Center – Rotterdam, Netherlands |
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| | Cornell University – Ithaca, New York, United States |
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| | STEMCELL Technologies, Inc. – Boston, Massachusetts, United States |
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