 | | Vol. 16.25 – 29 June, 2022 |
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| Researchers investigated the effects of apolipoprotein E ε4 (APOE4) on brain cell types derived from population and isogenic human induced pluripotent stem cells, post-mortem brain, and APOE targeted replacement mice.
[Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists reported that temozolomide-resistant glioblastoma has guanine (G) mutations that disrupted the G-rich DNA G-quadruplex and splice sites that lead to deregulated alternative splicing.
[Science Advances] |
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| Investigators showed that upon induced pluripotent stem cells’ differentiation into neural progenitor cells, the deletion of 22q11.2 acted in trans to alter the abundance of transcripts associated with risk for neurodevelopmental disorders including autism.
[Nature Communications] |
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| The authors reported that the inhibition of Col1a1 eliminated oncostreams, reprogramed the malignant histopathological phenotype, reduced expression of the mesenchymal associated genes, induced changes in the tumor microenvironment, and prolonged animal survival.
[Nature Communications] |
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| Scientists reported that constitutive stathmin-2 loss resulted in early-onset sensory and motor neuropathy featuring impaired motor behavior and dramatic distal neuromuscular junction denervation of fast-fatigable motor units.
[Cell Reports] |
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| Researchers performed a comprehensive analysis of ΔExon27 at the single-molecule, cellular, and organism levels. Results showed that ΔExon27 was prone to form cytoplasmic aggregates and was neurotoxic.
[EMBO Reports] |
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| Scientists differentiated human-induced pluripotent stem cells (hiPSCs) derived from the two brothers into mesencephalic neural precursor cells and early postmitotic dopaminergic neurons and performed whole exome sequencing and transcriptomic and metabolomic analyses.
[npj Parkinson’s Disease] |
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| Investigators reported that knockdown of the glycogen phosphorylase liver isoform, but not the brain isoform, decreased clonogenic growth and survival of glioblastoma cell lines and sensitized them to ionizing radiation doses.
[Cell Death & Disease] |
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| The authors explored the misexpression of miRNAs in an induced pluripotent stem cell-based disease model of FUS ALS.
[Stem Cell Reports] |
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| Researchers reported that TTF1 suppressed proliferation, migration, and invasion of neuroblastoma (NB) cells, while induced cell cycle arrest, apoptosis, and autophagy of NB cells by regulating TrkA and the miR-204-TrkB axis.
[iScience] |
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| The authors reported that CDC20 knockdown did not increase temozolomide- and radiation-induced DNA damage, or alter DNA damage repair, but rather promoted cell death through accumulation of the pro-apoptotic protein, Bim.
[PLoS One] |
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| Scientists reported that C-X-C motif chemokine receptor 4 (CXCR4) mediated the upregulation of Kruppel like factor 5, a zinc-finger-containing transcription factor, to facilitate the proliferation of glioma initiating cells.
[Cell Biology International] |
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| Expression of the minimal combination of Sox9 and Nfib generated induced astrocytes with molecular, phenotypic, and functional properties resembling primary human astrocytes.
[Stem Cell Reports] |
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| The authors explore the various neuronal differentiation potentials of periodontal ligament stem cells for application in neural regeneration therapy.
[Stem Cell Research & Therapy] |
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| Lenica Research Group announced the launch of a new strategic partnership with Allegori, a pioneering neuroscience innovation company based in Port of Spain, Trinidad and Tobago.
[Lenica Research Group (GlobeNewswire, Inc.)] |
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| The University of Newcastle officially announced that the frontline battle against brain cancer will be brought together as the new Mark Hughes Foundation Centre for Brain Cancer Research.
[The University of Newcastle, Australia] |
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| December 3 – 7, 2022
Washington, DC, United States |
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| | The Scripps Research Institute – La Jolla, California, United States |
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| | University of Missouri-Columbia – Columbia, Missouri, United States |
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| | University of California San Francisco – San Francisco, California, United States |
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| | The University of Arizona – Tucson, Arizona, United States |
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| Pennsylvania State University – State College, Pennsylvania, United States |
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Cancer Stem Cell News
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