 | | Vol. 16.34 – 31 August, 2022 |
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| Scientists developed a cell culture system to ask how astrocyte protein secretion and gene expression change in three mouse models of genetic neurodevelopmental disorders.
[Nature Neuroscience] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors showed that chiral nanoparticles with strong chirality could efficiently accelerate the differentiation of mouse neural stem cells into neurons under near-infrared light illumination.
[Advanced Science] |
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| ATRX PHD finger (PHDmut) and K1584R proteins interacted with the DAXX histone chaperone but show reduced localization to pericentromeres. Neurodifferentiation was both delayed and compromised in PHDmut and K1584R, and manifested differently from complete ATRX loss.
[Nucleic Acids Research] |
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| The authors developed an integrated bioinformatics and experimental pipeline that enabled multiplex measurement of transduction efficiency and specificity, particularly by measuring how libraries of delivery vectors transduced libraries of diverse cell types.
[Gene Therapy] |
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| Researchers used two highly relevant human dopaminergic neuronal models to show that endogenous levels of α-synuclein could determine the sensitivity of dopaminergic neurons to ferroptosis.
[Cell Reports] |
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| Using cultured neurons and brain tissue from mouse models of Parkinson’s Disease (PD), the authors demonstrated that leucine-rich repeat kinase 2 (LRRK2)-mediated phosphorylation of β-amyloid precursor protein (APP) increased the abundance and activity of the APP intracellular domain that then directly mediated LRRK2 transcription.
[Science Signaling] |
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| Scientists developed an integrated bioinformatics and experimental pipeline that enabled multiplex measurement of transduction efficiency and specificity, particularly by measuring how libraries of delivery vectors transduced libraries of diverse cell types.
[Gene Therapy] |
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| Scientists showed that deletion of Fat3 gene in mouse neural tube depleted neural progenitors, accompanied by neuronal gene expression in the ventral ventricular zone of the spinal cord.
[Scientific Reports] |
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| Investigators reported that thymol treatment increased the expression of Bax and p53, and also increased apoptotic cell death, and excessive generation of reactive oxygen species in human malignant glioblastoma cells.
[Molecular Biology Reports] |
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| In addition to reviewing the structure and localization of TYROBP, the authors discuss their recent progress using mouse models of either cerebral amyloidosis or tauopathy that were engineered to be TYROBP-deficient or TYROBP-overexpressing.
[Molecular Neurodegeneration] |
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| Dr. Linda J. Van Eldik, director of the University of Kentucky Sanders-Brown Center on Aging, is part of a $1.5 million grant to help further research into a possible treatment for Alzheimer’s disease.
[News Medical Life Sciences] |
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| October 23 – 26, 2022
Granlibakken Tahoe, California, United States |
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| | STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada |
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| | Michigan State University – East Lansing, Michigan, United States |
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| | Boston Children’s Hospital – Boston, Massachusetts, United States |
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| | Novartis – Cambridge, Massachusetts, United States |
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| | Yale University – New Haven, Connecticut, United States |
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