 | | Vol. 16.32 – 17 August, 2022 |
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| Scientists present a screening platform to systematically elucidate functional consequences of genetic perturbations in human induced pluripotent stem cell (iPSC)-derived microglia.
[Nature Neuroscience] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Using the SOMAscan proteomic platform, the authors measured concentrations of 25 TGF-β signaling family proteins in four different cohorts composed in total of 754 Caucasian or Pima Indian individuals with type 1 or type 2 diabetes.
[Science Translational Medicine] |
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| Researchers revealed that purinergic signaling in gliomas was shaped by genotype, lineage, and functional state, and that core enzymes expressed by tumor and myeloid cells were organized to promote adenosine-rich microenvironments potentially amenable to therapeutic targeting.
[Nature Communications] |
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| Scientists observed a shortening of prostate cancer (PC). Scientists detected a shortening of PC in PINK1-deficient human cellular and mouse models of familial Parkinson’s disease.
[Nature Communications] |
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| The authors identified the ubiquitin-specific peptidase 21 as a critical FOXD1 deubiquitinase in mesenchymal properties of glioblastoma stem cells.
[Cell Death & Differentiation] |
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| Telomerase repeated amplification protocol and C-circle assays were used to profile and characterize the TMM cross-sectionally and temporally across glioma samples.
[Genome Medicine] |
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| Investigators analyzed epilepsy data of an existing cohort including IDHwt histologically lower-grade glioma WHO grade 2 and 3 with molecular glioblastoma-like profile, IDHwt hLGG, and IDHwt glioblastoma patients.
[Neuro-Oncology] |
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| Researchers uncovered that APOE4 specifically downregulated TAGLN3, involving histone deacetylases activity, which results in low-grade chronic inflammation and hyperactivated inflammatory responses.
[Cell Reports] |
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| Using single-cell resolution of mouse Neuronopathic Gaucher disease brains, lipidomics, and newly generated biomarkers, scientists found induction of neuroinflammation pathways involving microglia, NK cells, astrocytes, and neurons.
[eLife] |
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| Researchers investigated whether there were naturally occurring SARM1 alleles within the human population that encoded SARM1 variants with loss-of-function.
[Scientific Reports] |
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| Scientists aimed at deciphering the unique role of endoplasmic reticulum stress in Alzheimer’s disease (AD) pathogenesis, reviewing key findings, and existing controversy in an attempt to summarize plausible therapeutic interventions in the management of AD pathophysiology.
[Cell Death & Disease] |
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| Amylyx Pharmaceuticals, Inc. announced a two-year sponsored research agreement with Sunnybrook Research Institute to expedite the identification of novel drug candidates that inhibit Bax and Bak for the development as therapeutics for neurodegenerative diseases.
[Amylyx Pharmaceuticals, Inc. (BusinessWire, Inc.)] |
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| | Shenzhen Institute of Advanced Technology – Shenzhen, China |
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| | Duke University – Durham, North Carolina, United States |
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| | NIH National Cancer Institute – Bethesda, Maryland, United States |
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| | Dalla Lana School of Public Health – Toronto, Ontario, Canada |
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| | National University of Ireland Galway – Galway, Ireland |
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