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| Investigators identified the protein Gibbin, encoded by the Xia–Gibbs AT-hook DNA-binding-motif-containing 1 disease gene7,8,9, as a key regulator of early epithelial morphogenesis.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers generated human PSC-derived hepatic organoids (hHOs) with a high drug metabolic ability. They established a two-step protocol to produce hHOs from human PSCs for long-term expansion and drug testing.
[Biomaterials] |
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| An analysis included recovery of precursor-enriched transcriptional regulatory proteins not found to be differentially expressed in previous transcriptomic datasets.
[Cell Reports] |
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| Investigators showed that cilia were present on the apical surface of radial glial cells in human fetal forebrain. Interfering with cilia signaling in human organoids by mutating the INPP5E gene led to the formation of ventral telencephalic cell types instead of cortical progenitors and neurons.
[Cell Reports] |
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| By exposing human intestinal organoids to polystyrene nanoplastics with concentrations of 10 and 100 μg/mL, researchers presented evidence of their distinct accumulation in various type cells in intestinal organoids, then causing the cell apoptosis and inflammatory response.
[Science of the Total Environment] |
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| Scientists developed a co-culture method with patient-derived cholangiocarcinoma organoids and immune cells, which could represent anti-cancer immunity in vitro.
[British Journal of Cancer] |
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| Organoids from the epithelioid sarcoma could be serially cultured and maintained in collagen type 1 gels for more than three passages. Developed orthotopic tumor xenografts were detected in the NOD-scid IL2Rgnull mice.
[Frontiers in Oncology] |
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| The authors established mouse pancreatic ductal organoids with progenitor characteristics and an insulin promoter-driven enhanced green fluorescent protein reporter system to screen astragalus saponin components for monomers that could promote insulin-producing cell differentiation.
[Phytomedicine] |
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| High nuclear receptor corepressor 2 (NCOR2) in the tumors of patients with breast cancer predicted chemotherapy refractoriness, tumor recurrence and poor prognosis.
[Nature Cancer] |
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| Scientists discuss various historical aspects of 3D organoid culture, how it has been applied to the hepatobiliary system, and how organoid technology intersects with the emerging global field of liver regenerative medicine.
[Hepatology] |
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| When coupled with the ability to propagate prions in cells or organoids derived from stem cells, these next-generation cellular models should provide an ideal paradigm for identifying small molecules and other biological therapeutics capable of interfering with prion replication in animal and human prion disorders.
[Cell and Tissue Research] |
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| For his contributions to the field of brain development, Jürgen Knoblich was presented with the City of Vienna Award.
[Institute of Molecular Biotechnology] |
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| The creator of a mini-brain model used to study Alzheimer’s disease is the winner of the 2022 O. Max Gardner Award, the most prestigious annual prize for faculty awarded by the 17-campus University of North Carolina System.
[North Carolina Agricultural and Technical State University] |
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| June 22 – 26
London, England, United Kingdom |
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| | Max Delbrück Center for Molecular Medicine – Berlin, Germany |
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| | University of Plymouth – Plymouth, England, United Kingdom |
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| | Jülich Research Centre – Jülich, Germany |
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| | Hubrecht Organoid Technology – Utrecht, Netherlands |
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