 | | Vol. 3.23 – 16 June, 2022 |
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| Researchers presented an automated multi-scale 3D imaging platform synergizing high-density organoid cultures with rapid and live 3D single-objective light-sheet imaging.
[Nature Methods] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators showed that a short and early Dual SMAD and WNT inhibition course was necessary and sufficient to establish robust and lasting cortical organoid neural stem cells (NSC) identity, efficiently suppressing non-cortical NSC fates.
[Nature Cell Biology] |
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| Scientists explored cell-cell and cell-matrix dependence in 58 gastric cancer organoids by withdrawing either ROCK inhibitor, matrix or both to evaluate their tumorigenic potential.
[Gut] |
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| The authors established a simple 3D culture system that allowed for the generation and manipulation of neuroepithelial (NE) organoids from hiPSCs, displaying developmental phases of hiPSC differentiation and self-aggregation, first into NE cysts with lumen structure and then toward NE organoids with floor-plate patterning.
[Advanced Science] |
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| Investigators developed a novel engineering method of creating the chimeric human cerebral organoids to assess the differential roles of APOE4 in neurons and astrocytes.
[Signal Transduction and Targeted Therapy] |
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| Investigators found that RNF43_p.G659fs promoted cell growth independent of Wnt signaling. PI3K/mTOR inhibitors yielded promising antitumor activity in RNF43659mut isogenic cell lines and xenograft models, as well as in patient-derived organoids harboring RNF43_p.G659fs mutations.
[Nature Communications] |
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| Scientists established long-term murine and human salivary gland organoid cultures that expressed gland-specific genes and proteins of acinar, myoepithelial, and duct cells, and exhibited gland functions when stimulated with neurotransmitters.
[Nature Communications] |
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| Investigators established a framework to identify constraints on an organoid’s morphological features by quantifying them from microscopy images of organoids exposed to a range of perturbations.
[Cell Systems] |
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| Researchers developed a novel immune-enhanced tumor organoid system to study factors affecting immune checkpoint blockade response.
[Scientific Reports] |
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| The authors review the molecular and cell biological features of basal radial glia that have recently been elucidated using brain organoids.
[Frontiers in Cell and Developmental Biology] |
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| Umoja Biopharma, Inc. and TreeFrog Therapeutics announced that they have entered into a collaboration to evaluate Umoja’s iPSC platform within TreeFrog’s C-Stem™ technology for scalable expansion and immune cell differentiation in bioreactors.
[Umoja Biopharma, Inc.] |
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| September 15 – September 17
Dublin, Ireland, United Kingdom |
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| | University Hospital of Würzburg – Würzburg, Germany |
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| | Uppsala University – Uppsala, Sweden |
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| | Francis Crick Institute – London, England, United Kingdom |
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| | Temple University – Philadelphia, Pennsylvania, United States |
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| | Electrophysiology and Heart Modeling Institute – Bordeaux, France |
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