Organoid News Volume 3.25 | Jun 30 2022

    By
    lbeveridge
    -
    0
    26







    2022-06-30 | ON 3.25


    Organoid News by STEMCELL Technologies
    Vol. 3.25 – 30 June, 2022
    TOP STORY

    Lymphatics Act as a Signaling Hub To Regulate Intestinal Stem Cell Activity

    Employing in vivo loss of function and lymphatic: organoid cocultures, researchers showed that crypt lymphatics maintained intestinal stem cells and inhibited their precocious differentiation.
    [Cell Stem Cell]

    AbstractGraphical Abstract
    Register Now for Oxford Global's 3D Cell Culture
    PUBLICATIONSRanked by the impact factor of the journal

    MECP2-Related Pathways Are Dysregulated in a Cortical Organoid Model of Myotonic Dystrophy

    The authors showed that CUG foci found early in the maturation of 3D cortical organoids from DM1 patient–derived iPSCs caused hyperphosphorylation of CUGBP Elav-like family member 2 protein.
    [Science Translational Medicine]

    AbstractPress Release

    Methionine Oxidation Activates Pyruvate Kinase M2 to Promote Pancreatic Cancer Metastasis

    Chemoproteomic profiling of pancreatic organoids revealed that ethionine sulfoxide reductase A loss resulted in the selective oxidation of a methionine residue in pyruvate kinase M2.
    [Molecular Cell]

    Abstract

    Occult Polyclonality of Preclinical Pancreatic Cancer Models Drives In Vitro Evolution

    Scientists applied single-cell sequencing technologies to reveal inherent heterogeneity in assumptively monoclonal pancreatic cancer cell lines and patient-derived organoids.
    [Nature Communications]

    Full Article

    A Bipotential Organoid Model of Respiratory Epithelium Recapitulates High Infectivity of SARS-CoV-2 Omicron Variant

    Investigators defined a ‘distal’ differentiation approach to generate alveolar organoids from the same source for the derivation of airway organoids.
    [Cell Discovery]

    Full Article

    Kinome Profiling of Cholangiocarcinoma Organoids Reveals Potential Druggable Targets That Hold Promise for Treatment Stratification

    Kinase activity in patient-derived cholangiocarcinoma organoids, non-tumorous adjacent tissue-derived and healthy donor-derived intrahepatic cholangiocyte organoids was determined using the PamChip® phosphotyrosine kinase microarray platform.
    [Molecular Medicine]

    Full Article

    Identification and Characterization of Stem Cells in Mammalian Esophageal Stratified Squamous Epithelia

    Researchers identified a slow-cycling/quiescent stem cell population that contained high levels of hemidesmosomes and low levels of Wnt signaling localized spatially and randomly at the basal layer of the esophageal epithelium.
    [Journal of Molecular Cell Biology]

    Abstract

    Understanding Primary Blast Injury: High Frequency Pressure Acutely Disrupts Neuronal Network Dynamics in Cerebral Organoids

    The authors used a computer-controlled table-top pressure chamber to expose human stem cell-derived cerebral organoids to varied frequency of pressure waves and characterize the neurophysiological response.
    [Journal of Neurotrauma]

    Abstract

    Raman Microspectroscopy Fingerprinting of Organoid Differentiation State

    Using complex 3D submandibular salivary gland organoids developed from embryonic progenitor cells, scientists developed Raman confocal microspectroscopy methods to define Raman signatures for each of these organoid states using both fixed and live organoids.
    [Cellular & Molecular Biology Letters]

    Full Article
    PneumaCult for primary airway epithelial cell culture at the air-liquid interface or as airway organoid.
    REVIEWS

    Biofabrication Approaches and Regulatory Framework of Metastatic Tumor-on-a-Chip Models for Precision Oncology

    Investigators present the commonly used alternatives and latest advances in biofabrication of tumor-on-chips, which allow the generation of the most sophisticated and optimized models for recapitulating the tumor process.
    [Medicinal Research Reviews]

    Full Article

    Metabolomics-Based Mass Spectrometry Methods to Analyze the Chemical Content of 3D Organoid Models

    Scientists highlight the separation- and imaging-based MS-based metabolomics methods that have been used to analyze the chemical contents of organoids.
    [Analyst]

    AbstractGraphical Abstract
    INDUSTRY AND POLICY NEWS

    iTolerance and LyGenesis Announce a Joint Research Collaboration to Regrow Functioning, Ectopic Livers Without the Need for Immune Suppression

    iTolerance, Inc. and LyGenesis, Inc. announced that they have entered into a joint research collaboration to evaluate the potential of iTOL-201, the product candidate in development using iTolerance’s SA FasL microgel immune tolerance platform combined with LyGenesis’ liver cell therapy.
    [iTolerance]

    Press Release
    FEATURED EVENT

    49th European Muscle Conference

    September 23 – 26, 2022
    Prague, Czech Republic

    > See All Events

    JOB OPPORTUNITIES

    Research Technician – Tissue Biology and Disease Modelling

    European Molecular Biology Laboratory – Barcelona, Spain

    Cell Biologist – Alzheimer’s Disease

    Icahn School of Medicine at Mount Sinai – New York, New York, United States

    Postdoctoral Training Fellow – Patient Derived Models

    Institute of Cancer Research – London, England, United Kingdom

    Postdoctoral Fellow – Cancer Biology and Cancer Immunology

    Icahn School of Medicine at Mount Sinai – New York, New York, United States

    Professor – Experimental Diabetes Research

    Uppsala University – Uppsala, Sweden

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    STEMCELL Organoids Twitter