 | | Vol. 3.35 – 8 September, 2022 |
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| Scientists described the tissue engineering of human thymus organoids from PSCs that could support the de novo generation of a diverse population of functional human T cells.
[Nature Methods] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators developed a panel of CDK4/6i-resistant breast cancer cell lines and patient-derived organoids and demonstrated that a subset of resistant models accumulated mitotic segregation errors and micronuclei.
[Science Advances] |
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| Using single primary murine pancreatic ductal adenocarcinoma cells embedded in a collagen matrix and adapted media supplementation, scientists generated organoids that self-organized into highly branched structures displaying a seamless lumen connecting terminal end buds.
[Nature Communications] |
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| Investigators performed a transcriptome-wide screen for genes of unknown function that possess inverse expression patterns in differentiating keratinocytes compared with cutaneous squamous cell carcinomas.
[Cancer Research] |
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| Murine intestinal and pulmonary organoids were harnessed to demonstrate that the epithelial niche was sufficient to drive tissue-specific maturation of all innate lymphoid cell groups in parallel, without requiring subset-specific cytokine supplementation.
[Cell Reports] |
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| Researchers presented a new in vitro model of the small intestine based on primary epithelial cells, apically accessible, with native tissue mechanical properties and controlled mesh size, 3D villus-like architecture, and precisely controlled biomolecular gradients of the intestinal stem cell niche.
[Advanced Healthcare Materials] |
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| The authors examined the potential of mouse epiblast stem cells cultured in media containing Wnt pathway inhibitors as a starting point for directed differentiation.
[Development] |
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| 52 organoids were established from 153 primary liver cancer patients. Compared with establishing patient-derived xenograft models, establishing organoids of hepatocellular carcinoma showed a trend toward a higher success rate and took less time.
[Cellular Oncology] |
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| Investigators reported a method for creating a perfusable 3D proximal tubule model composed of epithelial cells isolated from kidney organoids matured under static conditions.
[Scientific Reports] |
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| Scientists reported a pivotal role of fused in sarcoma (FUS) in regulating the human cortical brain and spinal cord development via the human iPSCs-derived organoids.
[Molecular and Cellular Neuroscience] |
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| The authors review progress made over the past decade in the generation and use of stem cell-derived metabolic cell types and organoids in metabolic disease research, especially obesity and liver diseases.
[Nature Reviews Endocrinology] |
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| Three scientific teams that developed physiologically competent retinal organoid systems have won the final phase of the 3D Retinal Organoid Challenge managed by the National Eye Institute.
[National Eye Institute] |
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| October 3 – 4, 2022
San Diego, California, United States |
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| | Max Delbrück Center for Molecular Medicine – Berlin, Germany |
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| | Lewis Katz School of Medicine, Temple University – Philadelphia, Pennsylvania, United States |
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| | Icahn School of Medicine at Mount Sinai – New York City, New York, United States |
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| | University of Copenhagen – Copenhagen, Denmark |
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| | Radboud University Medical Center – Nijmege, The Netherlands |
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