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| The authors used cell line models, tumor growth studies, and patient samples to assess the role of NF-κB kinase subunit-β (IKKβ) and its activation in cancer.
[Proceedings of the National Academy of Sciences of the United States of America] |
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|
 | | PUBLICATIONSRanked by the impact factor of the journal |
| |
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| Investigators demonstrated the derivation of a practical and durable hydrogel from decellularized human pancreas that supported human islet survival and function.
[Scientific Reports] |
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| Researchers identified novel strategies to prevent, delay or overcome resistance to gemcitabine, one of the most widely used medications in PDAC.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Scientists conducted mRNA whole transcriptomic bisulfite sequencing and categorized NOL1/NOP2/Sun domain family member 2 (NSUN2) target sites in the mRNA of human pancreatic cancer cells.
[Oncogene] |
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| The authors demonstrated that nuclear factor of activated T cells, cytoplasmic 3 (NFATc3) was activated in human PDAC cells and that excessive activation of NFATc3 was correlated to advanced stages of PDAC.
[Cell Death & Disease] |
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| Scientists investigated the specific molecular mechanism and the roles of extracellular matrix protein Spondin 1 (SPON1) in the development of PDAC.
[Cell Proliferation] |
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| Investigators explored the impact of interleukin 1 receptor-associated kinase 2 (IRAK2) on the biological behavior of PDAC and investigated the underlying mechanism.
[Cellular Oncology] |
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| MicroRNAs are known to be involved in the development and progression of pancreatic cancer (PC). Researchers explored the prognostic significance and mechanistic role of microRNA-569 in PC.
[Aging] |
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| To further elucidate the roles of TP53 in drug resistance of pancreatic cancer cells, scientists introduced wild-type P53 or a control vector into two different PDAC cell lines.
[Aging] |
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| The authors discuss the potential benefits of stimulator of interferon genes (STING) activation in PDAC, as well as describe the major components of the PDAC tumor microenvironment, and the expected consequences of STING activation.
[Cancer Letters] |
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| Investigators collect and analyze recent findings of the pancreatic cancer-stromal cell interactions mediated by extracellular vesicles and the mechanisms involved in cancer-related immunity and chemoresistance.
[Journal of Nanobiotechnology] |
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| Novo Nordisk announced headline results from the ONWARDS 2 trial, a Phase IIIa, 26-week efficacy and safety treat-to-target trial investigating once-weekly insulin icodec vs insulin degludec in 526 people with type 2 diabetes switching from daily insulin.
[Novo Nordisk A/S] |
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| September 19 – 20, 2022
Vejle, Denmark |
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| | Sidney Kimmel Cancer Center – Philadelphia, Pennsylvania, United States |
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| | Vanderbilt University – Nashville, Tennessee, United States |
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| | City of Hope – Duarte, California, United States |
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| | City of Hope – Duarte, California, United States |
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