 | | Vol. 13.27 – 2 August, 2022 |
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| The authors showed that Schwann cells activated by cancer cells collectively function as tumor activated schwann cell Tracks that promoted cancer cell migration and invasion.
[Cancer Discovery] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists report reduced miR-184-3p levels in human type 2 diabetes pancreatic islets, whereas its direct target CREB regulated transcription coactivator 1 (CRTC1) was increased and protects β-cells from lipotoxicity- and inflammation-induced apoptosis.
[Cell Death & Disease] |
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| Researchers reported a remarkable induction of the kmo gene in GK islets and in human islets exposed to proinflammatory conditions. It occurred prominently in beta cells.
[Biochimica Et Biophysica Acta-Molecular Basis of Disease] |
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| Investigators showed that cancer cell-intrinsic glutamic-oxaloacetic transaminase 2 shaped the immune microenvironment to suppress antitumor immunity.
[Cancer Discovery] |
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| Scientists constructed a high-resolution molecular landscape of the cellular subtypes and spatial communities that compose PDAC using single-nucleus RNA sequencing and whole-transcriptome digital spatial profiling.
[Nature Genetics] |
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| Researchers performed unbiased deubiquitinase library screening to explore the pivotal regulators of transcriptional coactivator with PDZ-binding motif (TAZ) ubiquitination as potential targets in PDAC models.
[Cell Death & Differentiation] |
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| The authors demonstrated that overexpression of nuclear factor kappa B 1 could promote the viability, migration, and invasion of gemcitabine-treated pancreatic cancer stem cells, but this effect could be partially abolished by miR-497 overexpression.
[Aging] |
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| Proteomic, cellular and biochemical analysis of the stress protein NUPR1 revealed that it bound to PARP1 into the nucleus and inhibited’ PARP1 activity in vitro.
[Communications Biology] |
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| Cryptotanshinone treatment decreased glutamine and lipid metabolism, affected redox regulation and increased reactive oxygen species production in the pancreatic cancer cell line MIAPaCa‑2 containing mutant Κirsten rat sarcoma viral oncogene homolog (KRAS).
[International Journal of Oncology] |
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| Cell biology function assays showed that knockdown of FTO-inhibited pancreatic cell abilities to migrate and invade in vitro.
[Cancer Medicine] |
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| Fibroblast growth factor receptor 3 was downregulated by RNA interference to explore its impact on cell proliferative proclivity in PDAC cells.
[Pancreas] |
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| The authors review the human islet amyloid polypeptide (hIAPP) physiology and the pathology that contributes to β-cell destruction, deciphering the various cellular steps that could be involved.
[Biochimica Et Biophysica Acta-Biomembranes] |
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| A major step toward transforming the understanding of cardiovascular and kidney disease in the millions of Americans with diabetes occurred when the National Institutes of Health designated the University of Florida (UF) Diabetes Institute the home for a new biobank of human heart and kidney tissue.
[University of Florida Health] |
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| October 24 – 26, 2022
Madrid, Spain |
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| | Karolinska Intitutet – Stockholm, Sweden |
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| | CRUK Manchester Institute – Manchester, United Kingdom |
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| | Sanford Research – Sioux Falls, South Dakota, United States |
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| | Carver College of Medicine – Iowa City, Iowa, United States |
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| | The Chinese University of Hong Kong – Hong Kong, China |
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