 | | Vol. 13.28 – 26 July, 2022 |
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| Scientists demonstrated that GSK126, a highly selective inhibitor of EZH2 methyltransferase activity influenced H3K27me3 chromatin content and transcriptional control resulting in the expression of core β-cell markers and ductal progenitor genes.
[Signal Transduction and Targeted Therapy] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers characterized the bidirectional paracrine cross-talk by which α and β cells communicated to mediate the effects of the glucagon-like peptide-1 receptor (GLP-1R) agonist, liraglutide.
[Science Advances] |
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| Investigators reported that β-cell-specific Piezo1 -knockout mice showed impaired glucose tolerance in vivo and reduced glucose-induced insulin secretion, β-cell electrical activity and Ca2+ elevation in vitro.
[Nature Communications] |
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| Functional experiments on ex vivo cultured pancreatic explants indicated that tip cell-produced bone morphogenetic protein 7 limited development of endothelial cells.
[Scientific Reports] |
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| Scientists reported that knocking down glucose-6-phosphate dehydrogenase (G6PD) impeded pancreatic cancer metastasis, whereas forced G6PD expression promoted it.
[Science Advances] |
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| Researchers demonstrated that depletion of O-GlcNAcylation reduced malate dehydrogenase 1 activity, impaired glutamine metabolism, sensitized PDAC cells to oxidative stress, decreased cell proliferation and inhibits tumor growth in nude mice.
[Nature Chemical Biology] |
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| Investigators reported that thiostrepton reduced the viability and clonogenesis of pancreatic cancer cell lines, along with intracellular iron overload, increasing reactive oxygen species accumulation, malondialdehyde overexpression, and glutathione peroxidase depletion.
[Cell Death & Disease] |
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| The authors reported that Protocadherin 1 (PCDH1) expression was upregulated in PDAC tissues, and its expression levels were associated with the depth of tumour invasion and lymph node metastasis.
[Cell Death & Disease] |
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| The expression of Frizzled receptor 7 in pancreatic ductal adenocarcinoma and relating survival rate were analyzed by bioinformatics, histochemistry assay and follow-up study.
[Molecular Medicine] |
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| The molecular circuit of the glucose-stimulated insulin secretion in β-cells is described with emphasis on intermediates which are targetable for optical intervention.
[Molecular Metabolism] |
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| Propanc Biopharma, Inc. announced that successful production of a synthetic recombinant version of the proenzyme trypsinogen was completed via the Proenzyme Optimization Project 1 oint research and drug discovery program.
[Propanc Biopharma, Inc.] |
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| Aug 7 – 12, 2022
Steamboat Springs, Colorado, United States |
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| | Mayo Clinic – Scottsdale, Arizona, United States |
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| | Carver College of Medicine – Iowa City, Iowa, United States |
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| | The Chinese University of Hong Kong – Hong Kong, China |
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| | Albert Einstein College of Medicine – Bronx, New York, United States |
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| | Ohio State University Wexner Medical Center – Columbus, Ohio, United States |
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