Pancreatic Cell News Volume 13.34 | Aug 30 2022

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    2022-08-30 | PACN 13.34


    Pancreatic Cell News by STEMCELL Technologies
    Vol. 13.34 – 30 August, 2022
    TOP STORY

    Phosphomimetic Dicer S1016E Triggers a Switch to Glutamine Metabolism in Gemcitabine-Resistant Pancreatic Cancer

    Scientists observed that high Dicer levels in PDAC cells were positively correlated with advanced pancreatic cancer and acquired resistance to gemcitabine.
    [Molecular Metabolism]

    Full Article
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    PUBLICATIONSRanked by the impact factor of the journal

    Activation of Pancreatic Stellate Cells Attenuates Intracellular Ca2+ Signals Due to Downregulation of TRPA1 and Protects against Cell Death Induced by Alcohol Metabolites

    The authors investigated real-time Ca2+ signaling, changes in mitochondrial potential, and cell death induced by ethanol metabolites in quiescent vs TGF-β-activated pancreatic stellate cells.
    [Cell Death & Disease]

    Full Article

    Circular RNA hsa_circ_0007367 Promotes the Progression of Pancreatic Ductal Adenocarcinoma by Sponging MiR-6820-3p and Upregulating YAP1 Expression

    Using in vivo and in vitro data, scientists reported that hsa_circ_0007367 promoted the proliferation and metastasis of PDAC.
    [Cell Death & Disease]

    Full Article

    Opposite Effects of Src Family Kinases on YAP and ERK Activation in Pancreatic Cancer Cells: Implications for Targeted Therapy

    Investigators demonstrated that a combination of insulin and the G protein-coupled agonist neurotensin induced rapid activation of Src family of tyrosine kinases within PANC-1 cells.
    [Molecular Cancer therapeutics]

    Abstract

    Mechanism of Apoptosis Activation by Curcumin Rescued Mutant p53Y220C in Human Pancreatic Cancer

    Using different biophysical and cell-based studies, researchers demonstrated that curcumin bounds and rescued mutp53Y220C to an active wild-type conformation and restored its apoptotic transcription function in BxPC-3-pancreatic cancer cells.
    [Biochimica Et Biophysica Acta-Molecular Cell Research]

    AbstractGraphical Abstract

    Novel Nitric Oxide Donor, Nitrated Phenylbutyrate, Induces Cell Death of Human Pancreatic Cancer Cells and Suppresses Tumor Growth of Cancer Xenografts

    A nitrated form of phenylbutyrate was synthesized, and the authors examined the antitumor effect on human pancreatic cancer cells and xenografts.
    [Oncology Reports]

    Abstract

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    REVIEWS

    The Trilogy of P21 Activated Kinase, Autophagy and Immune Evasion in Pancreatic Ductal Adenocarcinoma

    Investigators summarize currently available studies that have assessed the potential connection between P21-activated kinase, autophagy, and immune evasion in PDAC biology to guide future research.
    [Cancer Letters]

    Abstract
    INDUSTRY AND POLICY NEWS

    Henry Ford Health + MSU Health Sciences Funds Five Cancer Research Grants

    Henry Ford Health + Michigan State University Health Sciences announced its funding of five cancer research grants of up to $100,000 each.
    [Michigan State University]

    Press Release
    FEATURED EVENT

    Pathology of Exocrine Pancreas – of Men and Mice

    December 1 – 3, 2022
    Madrid, Spain

    > See All Events

    JOB OPPORTUNITIES

    Research Associate – Molecular Diagnostics and Experimental Therapeutics

    Beckman Research Institute of City of Hope – Duarte, California, United States

    Research Technologist – Tissue and Cell Biology

    STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada

    Research Assistant Professor – Pancreatic Cancer Metabolism

    The University of Oklahoma – Oklahoma City, Oklahoma, United States

    Postdoctoral Scholar – Oncology

    University of California San Francisco – San Francisco, California, United States

    Associate Professor – Solid Cancer Tumor Development

    Michigan State University – East Lansing, Michigan, United States

    > See All Jobs

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