Prostate Cell News Volume 13.18 | May 20 2022

May 20, 2022

2022-05-20 | PCN 13.18

Prostate Cell News by STEMCELL Technologies

Vol. 13.18 – 20 May, 2022

TOP STORY

TUBB4A Interacts with MYH9 to Protect the Nucleus during Cell Migration and Promotes Prostate Cancer via GSK3β/β-Catenin Signaling

Researchers suggested an oncogenic role of tubulin beta class IVa (TUBB4A) and provided a potentially actionable therapeutic target for prostate cancers with TUBB4A overexpression.
[Nature Communications]

Full Article

Facts Vs. claims. Three scientists peer reviewed a life science vendor to get to the truth. See for yourself.

PUBLICATIONSRanked by the impact factor of the journal

H3K9 Methylation Drives Resistance to Androgen Receptor–Antagonist Therapy in Prostate Cancer

Investigators showed that androgen blockade in prostate cancer leads to derepression of retroelements followed by a double-stranded RNA-stimulated interferon response that blocks tumor growth.
[Proceedings of the National Academy of Sciences of the United States of America]

Full Article

The DNA/RNA Helicase DHX9 Contributes to the Transcriptional Program of the Androgen Receptor in Prostate Cancer

The authors investigated whether DHX9 modulated prostate cancer cell transcriptome. They performed RNA-sequencing analyses upon DHX9 silencing in the androgen-responsive cell line LNCaP.
[Journal of Experimental & Clinical Cancer Research]

Full Article

HDL-Mediated Reduction of Cholesterol Content Inhibits the Proliferation of Prostate Cancer Cells Induced by LDL: Role of ABCA1 and Proteasome Inhibition

Scientists investigated the ability of high-density lipoproteins (HDL) to modulate cholesterol content and metabolism in androgen receptor (AR)-positive and AR-null prostate cancer cell lines and the consequences on cell proliferation.
[Biofactors]

Full Article

Exosomes from Prostate Cancer Cell Lines: Isolation Optimization and Characterization

Investigators examined several isolation procedures, exosome storage conditions and other conditions affecting exosome production by prostate cell lines.
[Biomedicine & Pharmacotherapy]

Full Article Graphical Abstract

**Label-Free Discrimination of Tumorigenesis Stages Using In Vitro Prostate Cancer Bone Metastasis Model by Raman Imaging**

A comprehensive study comparing the classification of as received prostate cancer cells in a 2D model and cancer cells in a 3D bone mimetic environment was performed over various time intervals using principal component analysis.
[Scientific Reports]

Full Article

Lysine Demethylase 5A Promotes Prostate Adenocarcinoma Progression by Suppressing MicroRNA-330-3p Expression and Activating the COPB2/PI3K/AKT Axis in an ETS1-Dependent Manner

High lysine demethylase 5Aexpression was correlated with reduced survival and poor prognosis of patients with prostate adenocarcinoma.
[Journal of Cell Communication and Signaling]

Abstract

Direct Bone Marrow Injection of Human Bone Marrow-Derived Stromal Cells into Mouse Femurs Results in Greater Prostate Cancer PC-3 Cell Proliferation, but Not Specifically Proliferation within the Injected Femurs

Researchers provided useful insights into the role of humanizing murine bone marrow with human bone marrow-derived stromal cells to study human prostate cancer cell biology.
[BMC Cancer]

Full Article

Long Non-Coding RNA AC245100.4 Contributes to Prostate Cancer Migration via Regulating PAR2 and Activating p38-MAPK Pathway

The authors suggested that AC245100.4 and PAR2 served as oncogenic factors in cellular migration in prostate cancer cells.
[Medical Oncology]

Abstract

Double-Layer Omics Analysis of Castration- and X-Ray-Resistant Prostate Cancer Cells

LNCaP-LA showed X-ray resistance compared to LNCaP and sensitivity to carbon ion beams.
[Journal of Radiation Research]

Full Article

REVIEWS

Transcription Associated Cyclin-Dependent Kinases as Therapeutic Targets for Prostate Cancer

The authors summarize the roles of transcription associated cyclin-dependent kinases in regulating gene transcription and highlights rationales for their targeting in prostate cancer.
[Oncogene]

Full Article

Integration of Liquid Biopsies in Clinical Management of Metastatic Prostate Cancer

Scientists outline current data on liquid biopsies and their application to clinical management of metastatic prostate cancer.
[Current Oncology Reports]

Abstract

INDUSTRY AND POLICY NEWS

Sorrento Announces FDA Authorization to Proceed with Phase II Study of Abivertinib (Fujovee^™) to Treat Metastatic Castrate Resistant Prostate Cancer (MAVERICK Trial)

Sorrento Therapeutics, Inc. announced that it has received clearance from the FDA for its investigational new drug application for Abivertinib or the Phase II MAVERICK study to be conducted in participants with metastatic CRPC at multiple centers in the United States.
[Sorrento Therapeutics, Inc.]

Press Release

Teleflex Announces Regulatory Clearance for its UroLift^® System in China for the Treatment of Benign Prostatic Hyperplasia (BPH)

Teleflex Incorporated announced that it has received National Medical Products Administration approval for its UroLift^® System in China for treating BPH.
[Teleflex Incorporated]

Press Release

FEATURED EVENT

Prostate Cell News Volume 13.18 | May 20 2022

TUBB4A Interacts with MYH9 to Protect the Nucleus during Cell Migration and Promotes Prostate Cancer via GSK3β/β-Catenin Signaling

H3K9 Methylation Drives Resistance to Androgen Receptor–Antagonist Therapy in Prostate Cancer

The DNA/RNA Helicase DHX9 Contributes to the Transcriptional Program of the Androgen Receptor in Prostate Cancer

HDL-Mediated Reduction of Cholesterol Content Inhibits the Proliferation of Prostate Cancer Cells Induced by LDL: Role of ABCA1 and Proteasome Inhibition

Exosomes from Prostate Cancer Cell Lines: Isolation Optimization and Characterization

**Label-Free Discrimination of Tumorigenesis Stages Using In Vitro Prostate Cancer Bone Metastasis Model by Raman Imaging**

Lysine Demethylase 5A Promotes Prostate Adenocarcinoma Progression by Suppressing MicroRNA-330-3p Expression and Activating the COPB2/PI3K/AKT Axis in an ETS1-Dependent Manner

Direct Bone Marrow Injection of Human Bone Marrow-Derived Stromal Cells into Mouse Femurs Results in Greater Prostate Cancer PC-3 Cell Proliferation, but Not Specifically Proliferation within the Injected Femurs

Long Non-Coding RNA AC245100.4 Contributes to Prostate Cancer Migration via Regulating PAR2 and Activating p38-MAPK Pathway

Double-Layer Omics Analysis of Castration- and X-Ray-Resistant Prostate Cancer Cells

Transcription Associated Cyclin-Dependent Kinases as Therapeutic Targets for Prostate Cancer

Integration of Liquid Biopsies in Clinical Management of Metastatic Prostate Cancer

Sorrento Announces FDA Authorization to Proceed with Phase II Study of Abivertinib (Fujovee^™) to Treat Metastatic Castrate Resistant Prostate Cancer (MAVERICK Trial)

Teleflex Announces Regulatory Clearance for its UroLift^® System in China for the Treatment of Benign Prostatic Hyperplasia (BPH)

3D Cell Culture Symposium

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Postdoctoral Position – Cancer Biology

Postdoctoral Fellow – Prostate Cancer Biology

Postdoctoral Fellow – Prostate/Pancreatic Cancer

Faculty Positions – Cancer Research

Head of Department – Radiation Biology

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TUBB4A Interacts with MYH9 to Protect the Nucleus during Cell Migration and Promotes Prostate Cancer via GSK3β/β-Catenin Signaling

H3K9 Methylation Drives Resistance to Androgen Receptor–Antagonist Therapy in Prostate Cancer

The DNA/RNA Helicase DHX9 Contributes to the Transcriptional Program of the Androgen Receptor in Prostate Cancer

HDL-Mediated Reduction of Cholesterol Content Inhibits the Proliferation of Prostate Cancer Cells Induced by LDL: Role of ABCA1 and Proteasome Inhibition

Exosomes from Prostate Cancer Cell Lines: Isolation Optimization and Characterization

Label-Free Discrimination of Tumorigenesis Stages Using In Vitro Prostate Cancer Bone Metastasis Model by Raman Imaging

Lysine Demethylase 5A Promotes Prostate Adenocarcinoma Progression by Suppressing MicroRNA-330-3p Expression and Activating the COPB2/PI3K/AKT Axis in an ETS1-Dependent Manner

Direct Bone Marrow Injection of Human Bone Marrow-Derived Stromal Cells into Mouse Femurs Results in Greater Prostate Cancer PC-3 Cell Proliferation, but Not Specifically Proliferation within the Injected Femurs

Long Non-Coding RNA AC245100.4 Contributes to Prostate Cancer Migration via Regulating PAR2 and Activating p38-MAPK Pathway

Double-Layer Omics Analysis of Castration- and X-Ray-Resistant Prostate Cancer Cells

Transcription Associated Cyclin-Dependent Kinases as Therapeutic Targets for Prostate Cancer

Integration of Liquid Biopsies in Clinical Management of Metastatic Prostate Cancer

Sorrento Announces FDA Authorization to Proceed with Phase II Study of Abivertinib (Fujovee™) to Treat Metastatic Castrate Resistant Prostate Cancer (MAVERICK Trial)

Teleflex Announces Regulatory Clearance for its UroLift® System in China for the Treatment of Benign Prostatic Hyperplasia (BPH)

**Label-Free Discrimination of Tumorigenesis Stages Using In Vitro Prostate Cancer Bone Metastasis Model by Raman Imaging**

Sorrento Announces FDA Authorization to Proceed with Phase II Study of Abivertinib (Fujovee^™) to Treat Metastatic Castrate Resistant Prostate Cancer (MAVERICK Trial)

Teleflex Announces Regulatory Clearance for its UroLift^® System in China for the Treatment of Benign Prostatic Hyperplasia (BPH)