 | | Vol. 11.31 – 11 August, 2022 |
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| Researchers employed lineage-tracing mouse models to investigate the cell of origin of Eml4-Alk lung adenocarcinoma, and showed that Club and alveolar type 2 cells gave rise to tumors.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| In cultured human bronchial epithelial cells, cadherin-26 knockdown inhibited IL-13 induced IL-4Rα and IL-13Rα1 upregulation and suppressed downstream Jak1 and Stat6 phosphorylation.
[American Journal of Respiratory Cell and Molecular Biology] |
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| Scientists determined the expression of markers of inflammation in COPD patients with rapid functional decline in comparison to slow or no decliners.
[Respiratory Research] |
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| The authors reported that exposure to liquid nicotine or nicotine aerosol generated from e-cigarette induced downregulation of stem-loop binding protein and polyadenylation of canonical histone mRNAs in human bronchial epithelial cells and in mice lungs.
[Toxicological Sciences] |
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| Using a co-culture system, researchers identified that the TLR2/MMP9 axis in pulmonary monocytes promoted the epithelial mesenchymal transition (EMT) of pulmonary epithelial cells.
[Biochemical and Biophysical Research Communications] |
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| The authors investigated the mechanisms of action of all trans-retinoic acid in human lung epithelial cells exposed to hyperoxia.
[PLoS One] |
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| Investigators found that human plant homeodomain finger protein 1 (PHF1) was down-regulated in lung adenocarcinoma samples and low PHF1 expressions correlated with unfavorable clinical characteristics.
[Cell Death Discovery] |
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| Researchers showed that activity of the multi-kinase inhibitor Amuvatinib was enhanced by βIII-tubulin suppression in independent NSCLC cell lines.
[Cancer Medicine] |
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| Heart development protein with EGF-like domains 1 (HEG1) in lung tissues and cell lines of lung adenocarcinoma were significantly downregulated compared to benign pulmonary disease tissues and alveolar epithelial cells.
[Cancer Medicine] |
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| Scientists investigated the effects of copper (Cu) (II), naringenin, binary Cu(II)-naringenin complex, and the Cu(II)-naringenin containing bathophenanthroline as an auxiliary ligand on adenocarcinoma human alveolar basal epithelial cells (A549 cells) that were used as models for the study of drug therapies against lung cancer.
[Biometals] |
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| Researchers unraveled the precise function of circRNA CD226 in NSCLC pathogenesis.
[Anti-Cancer Drugs] |
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| The authors summarized experiences with anticytokine biologics to highlight which specific asthma outcomes they affected and how these effects reflected inflammatory pathways modified by biologics and related to pathophysiologic features of asthma.
[Journal of Allergy and Clinical Immunology] |
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| Scientists focus on immunotherapeutic targets in NSCLC tumors and discuss how NSCLC tumor microenvironment may influence patients’ response to immunotherapy.
[Immunology] |
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| Verona Pharma plc announced its top-line Phase III ENHANCE-2 (“Ensifentrine as a Novel inHAled Nebulized COPD thErapy”) trial results evaluating nebulized ensifentrine for the maintenance treatment of COPD.
[Verona Pharma plc] |
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| AstraZeneca and Daiichi Sankyo have delivered more evidence that their TROP2-directed antibody-drug conjugate may have a future in NSCLC, linking the candidate to a roughly 40% overall response rate when used as part of doublet and triplet combination therapies.
[Fierce Biotech] |
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| November 2 – 4, 2022
Lyon, France |
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| | NIH National Cancer Institute – Bethesda, Maryland, United States |
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| | University of Alberta – Edmonton, Alberta, Canada |
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| | Dalla Lana School of Public Health – Toronto, Ontario, Canada |
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| | King’s College London – London, United Kingdom |
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| | Albert Einstein College of Medicine – Bronx, New York, United States |
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