Umbilical & Placental Cell News Volume 14.20 | June 2 2022

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    2021-06-02 | UPCN 14.20


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    Vol. 14.20 – 2 June, 2022
    TOP STORY

    How Placenta Promotes the Successful Reproduction in High-Altitude Populations: A Transcriptome Comparison between Adaptation and Acclimatization

    Scientists compared the placental transcriptomes of Tibetans, sea level Hans, and Han immigrants. Among the three populations, placentas from ImHan showed a hyperactive gene expression pattern.
    [Molecular Biology and Evolution]

    Abstract

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    PUBLICATIONSRanked by the impact factor of the journal

    Regulation of Proton Partitioning in Kinase-Activating Acute Myeloid Leukemia and Its Therapeutic Implication

    Researchers reported a novel mechanism whereby kinase mutants induced intracellular alkalization characteristic in oncogenesis.
    [Leukemia]

    Full Article

    Human Umbilical Cord Mesenchymal Stem Cells-Derived Exosomes for Treating Traumatic Pancreatitis in Rats

    Investigators found that human umbilical cord MSCs-exosomes could colonize injured pancreatic tissue, inhibit the apoptosis of acinar cells, and control the systemic inflammatory response to facilitate the repair of pancreatic tissue.
    [Stem Cell Research & Therapy]

    Full Article

    SDF-1-Edited Human Amniotic Mesenchymal Stem Cells Stimulate Angiogenesis in Treating Hindlimb Ischaemia

    The authors generated long-term stromal cell-derived factor-1 secreting human amniotic MSCs via TALEN-mediated editing and investigated to determine whether gene-edited AMM/S are novel angio-vasculogenic cell population in experimental ischaemia.
    [Journal of Cellular and Molecular Medicine]

    Full Article

    Magnetic Exposure using Samarium Cobalt (SmCO5) Increased Proliferation and Stemness of Human Umbilical Cord Mesenchymal Stem Cells (hUC-MSCs)

    Researchers suggested that the magnetic fields could potentially induce proliferation of MSCs.
    [Scientific Reports]

    Full Article

    Indoxyl Sulfate Impairs In Vitro Erythropoiesis by Triggering Apoptosis and Senescence

    CD34+ hematopoietic stem cells were isolated from human umbilical cord blood and differentiated toward erythrocyte lineage for 14 days in various concentrations of indoxyl sulfate (IS). The effects of IS on cell proliferation, differentiation, apoptosis, and senescence were determined.
    [Experimental Biology and Medicine]

    Abstract

    Sex-Selective Increase of IGF-2 Expression in the Hypoxic Guinea Pig Placenta of Growth-Restricted Fetuses

    Scientists investigated the effects of chronic hypoxia and sex on protein expression of the Insulin-like growth factor (IGF-2) pathway in placentas selected from asymmetric-fetal growth restriction fetuses.
    [Reproductive Sciences]

    Abstract

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    REVIEWS

    Engineering the Next Generation of Cell-Based Therapeutics

    Despite notable recent clinical and commercial successes, cell-based therapies continue to face numerous challenges that limit their widespread translation and commercialization, including identification of the appropriate cell source, generation of a sufficiently viable, potent and safe product that meets patient- and disease-specific need.
    [Nature Reviews Drug Discovery]

    Full Article

    INDUSTRY AND POLICY NEWS

    Altos
    Labs Announces Sponsored Research Agreement with Kyoto University’s CiRA to Foster Cellular Rejuvenation Programming Research

    Altos Labsâ„¢ launched as a new biotechnology company dedicated to unraveling the deep biology of cellular rejuvenation programming with a mission to restore cell health and resilience to reverse disease, injury, and the disabilities that can occur throughout life.
    [Altos Labsâ„¢ (PR Newswire)]

    Press Release

    FEATURED EVENT

    Danish Stem Cell Society (DASCS) 2022

    September 19 – 20, 2022
    Vejle, Denmark

    > See All Events

    JOB OPPORTUNITIES

    Scientist – Fetal Cells in Maternal Blood

    Luna Genetics, Inc. – Houston, Texas, United States

    Tenure Track Faculty Position – Cell Signaling

    New York University College of Dentistry – New York, New York, United States

    Postdoctoral Fellow – Microenvironment and Signaling

    Albert Einstein College of Medicine – New York, New York, United States

    Postdoctoral Position – Computational Biology

    Harvard Medical School – Boston, Massachusetts, United States

    Postdoctoral Fellow – Immunology, Epigenetics, and Cellular Metabolism 

    Van Andel Institute – Grand Rapids, Michigan, United States

    > See All Jobs

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