Umbilical & Placental Cell News Volume 14.33 | Aug 25 2022

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    2022-08-25 | UPCN 14.33


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    Vol. 14.33 – 25 August, 2022
    TOP STORY

    αvβ3 Integrin-Specific Exosomes Engineered with Cyclopeptide for Targeted Delivery of Triptolide against Malignant Melanoma

    Researchers applied exosome derived from human umbilical cord MSCs and engineered them exogenously with a cyclic peptide, arginine-glycine-aspartate to encapsulate triptolide to establish a bionic-targeted drug delivery system, achieving synergism and toxicity reduction.
    [Journal of Nanobiotechnology]

    Full ArticleGraphical Abstract
    Find the Right Antibodies for Your Stem Cell Research. Learn More
    PUBLICATIONSRanked by the impact factor of the journal

    Post-Mitotic Centriole Disengagement and Maturation Leads to Centrosome Amplification in Polyploid Trophoblast Giant Cells

    The authors compared the characteristics and outcomes of andomized clinical trial (RCT) participants to a Francophone population-based registry of patients fulfilling the eligibility criteria used in their RCT and transplanted with one or two umbilical cord blood units after a myeloablative conditioning regimen.
    [Transplantation and Cellular Therapy]

    Abstract

    Comparable Survival Outcomes with Haploidentical Stem Cell Transplantation and Cord Blood Transplantation

    Scientists identified 136 patients aged between 16 and 69 years who received HLA-haploidentical stem cell transplantation using post-transplant cyclophosphamide as their first transplantation for acute leukemia or myelodysplastic syndromes.
    [Bone Marrow Transplantation]

    Full Article

    Macrophage Polarization in Placenta Accreta and Macrophage-Trophoblast Interactions

    The authors investigated the effects of HTR-8/SVneo trophoblasts cell line on macrophage human monocyte cell line polarization and granulocyte colony-stimulating factor secretion, and also analyzed the effects of THP-1 cells on primary trophoblasts and HTR-8 proliferation, invasion, and adhesion.
    [American Journal of Reproductive Immunology]

    Abstract

    Spontaneous Abortion Is Associated with Differentially Expressed Angiogenic Chemokines in Placenta and Decidua

    Researchers investigated the role of the angiogenic and angiostatic chemokines in placenta and decidua tissues from spontaneous and induced abortions.
    [Archives of Gynecology and Obstetrics]

    Abstract

    DEAE-Dextran Enhances the Lentiviral Transduction of Primary Human Mesenchymal Stromal Cells from All Major Tissue Sources without Affecting Their Proliferation and Phenotype

    Investigators explored a range of polycations, using transduction protocols with and without spinoculation, to produce stably transduced MSCs from derived from umbilical cord, bone marrow, and adipose tissue.
    [Molecular Biotechnology].
    [Molecular Biotechnology]

    Full Article
    Maximize Post-Thaw Cell Recovery with cGMP-Manufactured Cryopreservation Media. Learn More.
    REVIEWS

    Strategies for Immortalisation of Amnion-Derived Mesenchymal and Epithelial Cells

    Scientists summarize the current understanding of molecular mechanisms that contribute to cell immortalisation, the strategies that have been employed to immortalise amnion-derived cell types, and their likely applications in regenerative medicine.
    [Cell Biology International]

    Full Article
    INDUSTRY AND POLICY NEWS

    Amniotics Phase I/II Study of PulmoStem™ in Hospitalized COVID-19 Patients Ready to Start

    Amniotics AB announced that several batches of PulmoStem™ have been certified by the company’s qualified person and that clinical sites in the UK and Sweden are set to start the enrollment of subjects in the first-in-human Phase I/II study of hospitalized COVID-19 patients.
    [Amniotics AB]

    Press Release
    FEATURED EVENT

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    JOB OPPORTUNITIES

    Research Technologist – Center for Regenerative Medicine

    Harvard Stem Cell Institute – Boston, Massachusetts, United States

    Associate Director – Management of PSC Biology

    STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada

    Assistant Member – Genes and Human Disease Research Program

    Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States

    Faculty Member – Faculty of Life and Health Sciences

    Shenzhen Institute of Advanced Technology – Shenzhen, China

    Research Technologist – Center for Regenerative Medicine

    Harvard Stem Cell Institute – Boston, Massachusetts, United States

    > See All Jobs

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