Umbilical & Placental Cell News Volume 14.39 | Oct 6 2022

    0
    86








    2022-10-06 | UPCN 14.39


    Umbilical-and-Placental-Cell-News-email-header (1)
    Vol. 14.39 – 6 October, 2022
    TOP STORY

    Vitality-Enhanced Dual-Modal Tracking System Reveals the Dynamic Fate of Mesenchymal Stem Cells for Stroke Therapy

    A vitality-enhanced dual-modal tracking system was designed to improve engraftment efficiency and was utilized to noninvasively explore the fate of intravenous transplanted human umbilical cord-derived MSCs during long-term treatment of ischemic stroke.
    [Small]

    Abstract
    Microscopy images of pluripotent stem cells (PSCs) and PSC-derived cells for the #StemCellfie contest.
    PUBLICATIONSRanked by the impact factor of the journal

    Transplantation of Wharton’s Jelly Mesenchymal Stem Cells Encapsulated with Hydroactive® Gel Promotes Diabetic Wound Antifibrotic Healing in Type 2 Diabetic Rats

    Biocompatibility experiments showed that Wharton’s jelly MSCs (WJMSCs) embedded in Hydroactive® Gel did not influence the cell viability, survival, proliferation, and apoptosis of WJMSCs in vitro.
    [Journal of Materials Chemistry B]

    AbstractGraphical Abstract

    miR-146a-5p-Modified hUCMSC-Derived Exosomes Facilitate Spinal Cord Function Recovery by Targeting Neurotoxic Astrocytes

    Investigators determined that human umbilical cord MSC-derived exosomes reduced the deleterious effects of neurotoxic astrocytes in vitro and in vivo.
    [Stem Cell Research & Therapy]

    Full Article

    Systematic Comparation of the Biological and Transcriptomic Landscapes of Human Amniotic Mesenchymal Stem Cells under Serum-Containing and Serum-Free Conditions

    The authors preconditioned human amniotic MSCs under serum-containing and serum-free medium for 48 hours and compared the biological signatures and biofunctions from the view of cell morphology, immunophenotypes, and multi-lineage differentiation in vitro.
    [Stem Cell Research & Therapy]

    Full Article

    Validation of a Rapid Potency Assay for Cord Blood Stem Cells Using Phospho Flow Cytometry: The IL-3-pSTAT5 Assay

    Public cord blood banks are required to measure cord blood units potency before their release, thus researchers developed a rapid flow cytometry assay based on the measurement of STAT-5 phosphorylation of CD34+ stem cells in response to IL-3 stimulation.
    [International Journal of Laboratory Hematology]

    Abstract

    Effect of Human Umbilical Cord Mesenchymal Stem Cell Exosomes on Aerobic Metabolism of Human Retinal Pigment Epithelial Cells

    Scientists investigated the effect of exosomes secreted by human umbilical cord MSC on aerobic metabolism of cobalt chloride-induced oxidative damage in the human retinal pigment epithelial cell line.
    [International Ophthalmology]

    Abstract
    Subscribe to the Stem Cell Podcast YouTube Channel
    REVIEWS

    Role of ADAM and ADAMTS Disintegrin and Metalloproteinases in Normal Pregnancy and Preeclampsia

    Identifying the role of a disintegrin and metalloproteinase (ADAM) and ADAM with thrombospondin motifs (ADAMTS) in normal pregnancy and preeclampsia has led to a better understanding of the underlying molecular and vascular pathways, and advanced the potential for novel biomarkers.
    [Biochemical Pharmacology]

    AbstractGraphical Abstract
    INDUSTRY AND POLICY NEWS

    CCRF Awards Eight New Emerging Scientists

    Through a selective granting process, Children’s Cancer Research Fund (CCRF) recently awarded these eight promising scientists the Emerging Scientist Award, each worth $100,000, to pursue their research.
    [Children’s Cancer Research Fund]

    Press Release
    FEATURED EVENT

    12th AACR-JCA Conference: Breakthroughs in Cancer Research

    December 10 – 14, 2022
    Maui, Hawaii, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Associate – Hematopoietic Stem Cells

    Baylor College of Medicine – Houston, Texas, United States

    Faculty Position – Molecular Biology of Reproduction

    UT Southwestern Medical Center – Dallas, Texas, United States

    Postdoctoral Researcher – Muscle, Endothelial, and Hematopoietic Cells

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

    Postdoctoral Research Fellow – Bioinformatics

    The University of British Columbia – Vancouver, British Columbia, Canada

    Research Technologist – Center for Regenerative Medicine

    Harvard Stem Cell Institute – Boston, Massachusetts, United States

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Cord Blood News Twitter