Mast Cell Infiltration of the Choroid and Protease Release Are Early Events in Age-Related Macular Degeneration Associated with Genetic Risk at Both Chromosomes 1q32 and 10q26

Investigators found that increased mast cell infiltration of the inner choroid, degranulation, and subsequent extracellular matrix remodeling were early events in age-related macular degeneration (AMD) pathogenesis and represented a unifying mechanistic link between chromosome (Chr)1- and Chr10-mediated AMD.