Derivation of Functional Trophoblast Stem Cells from Primed Human Pluripotent Stem Cells
Scientists showed that the trophoblast cells cells resembled placenta- and naive human PSC-derived trophoblast stem cells, based on their transcriptome as well as their in vitro and in vivo differentiation potential.
[Nature Communications] Investigators reported that miR-21 enhanced glucose uptake and subsequently promoted insulin secretion by up-regulating Glut2 expression in a miR-21-Pdcd4-AP-1 dependent pathway.
[Immunity] Single-cell RNA sequencing revealed the heterogeneity of pancreatic stellate cell (PSCs) and identified very-low-density lipoprotein receptor+ PSCs that were characterized by a higher lipid metabolism.
[Cancer Letters] The authors reported that aortic carboxypeptidase–like protein (ACLP) was mainly expressed in cancer-associated fibroblasts (CAFs) but not in cancer cells and highly expressed in pancreatic ductal adenocarcinoma (PDAC) tissues.