Epithelial De-Differentiation Triggered by Co-ordinate Epigenetic Inactivation of the EHF and CDX1 Transcription Factors Drives Colorectal Cancer Progression

Scientists identified co-ordinate epigenetic inactivation of two epithelial-specific transcription factors, Ets homologous factor (EHF) and caudal type homeobox 1 (CDX1), as a mechanism driving differentiation loss in colorectal cancers.