The Epigenetic Modifier HDAC2 and the Checkpoint Kinase ATM Determine the Responses of Microsatellite Instable Colorectal Cancer Cells to 5-Fluorouracil

Researchers showed that long-term and short-term cultures of colorectal cancers with microsatellite instability contained subpopulations of cells lacking histone deacetylase-2 (HDAC2).