Sorafenib and Nitazoxanide Disrupt Mitochondrial Function and Inhibit Regrowth Capacity in Three-Dimensional Models of Hepatocellular and Colorectal Carcinoma

Cells grown in 3D cultures were sensitive to the oxidative phosphorylation inhibitor nitazoxanide, sorafenib, and regorafenib and resistant to other multikinase inhibitors and chemotherapeutic drugs.