Direct Transcriptomic Comparison of Xenobiotic Metabolism and Toxicity Pathway Induction of Airway Epithelium Models at an Air–Liquid Interface Generated From Induced Pluripotent Stem Cells and Primary Bronchial Epithelial Cells

TInvestigators reported a comparative analysis by TempoSeq, oligo-directed sequencing, of an iPSC-derived airway model with a primary bronchial airway model. The iBAE and pBAE were differentiated at an air–liquid interface and then evaluated in a 5-compound screen with exposure to a sub-lethal concentration of each compound for 24 hours.