Calreticulin Enhances Gastric Cancer Metastasis by Dimethylating H3K9 in the E-cadherin Promoter Region Mediating by G9a

Investigators discovered that calreticulin (CALR) was highly expressed in gastric cancer (GC) tissues and related to lymph node metastasis and patient’s terrible prognosis. The introduction of CALR dramatically promoted GC cell migration in vitro and in vivo, while the repression of CALR got the opposite effects.