Newsletters

[Cell] Scientists revealed that glioma-generated guanidinoacetate (GAA) excites surrounding neurons. After depleting tumoral GAA, they found decreased electrochemical activity, neuron-glioma interactions, and tumor aggressiveness.

[Cell] Researchers used systematic whole-brain axon tracing and integrated analyses to show that the serotonergic projectome is organized by functional relatedness rather than the physical proximity of its targets.

[Neuron] The authors developed an approach to transiently inhibit the cilia beating of ependymal cells (ECs) lining the forebrain ventricle, showing that EC cilia beating regulates neural stem cell (NSC) quiescence and activation dynamics.

[Neuron] Investigators showed that adult gliomas receive functional γ-aminobutyric acid synaptic input from local inhibitory interneurons and that this input acts as a tumor-suppressive circuit signal.

[Nature Communications] The authors showed mitochondrial transfer between Glioblastoma (GBM) cells and non-tumoral astrocytes (AS), finding transfer from GBM cells to AS is associated with activation of mitophagy in recipient cells and AS to GBM transfer is correlated with changes in mitochondrial activity and metabolism.

[Science Advances] Scientists studied the ability of dopamine to modulate SNr neuron activity in ex vivo mouse brain slices, demonstrating that dopaminergic modulation of astrocytes plays a key role in modulating SNr circuits and motor behavior.

[Science Advances] Researchers used multiple high-resolution imaging techniques to demonstrate that dendrites in cortical and hippocampal neurons exhibit nanoscale constrictions, termed dendritic shaft constrictions (DSCs), in mice and in human hippocampal and cortical neurons.

[Developmental Cell] Investigators showed that protein turnover is faster in mouse neural progenitors compared to human, driven by higher rates of protein synthesis and degradation.

[Autophagy] The authors used integrative analyses encompassing clinical specimens, public single-cell RNA-seq datasets, orthotopic glioma models, primary CD8+ T cell co-culture systems, and tandem mass tag proteomics to find that CD81 was highly expressed in radioresistant GBM and governed GBM immune evasion.

[Experimental & Molecular Medicine] Researchers created TRANsCre-DIONE, a dual-promoter split-Cre system combining GFAP and Lcn2 regulatory elements with Cre-dependent Neurog2 expression under the EF1α promoter, enabling selective targeting of scar-forming reactive astrocytes.

[Trends in Cell Biology] Scientists summarize recent findings suggesting that aging progressively erodes RNA regulatory fidelity through alterations in RNA-binding protein abundance, localization, biophysical behavior, and RNA interactions, arguing that this is a driver of neuronal vulnerability and neurodegeneration.

[Experimental Neurology] The authors examine midbrain organoid-based parkinson's disease modeling through a concept-driven lens, distinguishing established findings from emerging technologies and providing a realistic assessment of current limitations.