CD81 Drives Immune Evasion in Radioresistant Glioblastoma by Blocking Selective Autophagic Degradation of CD274/PD-L1

The authors used integrative analyses encompassing clinical specimens, public single-cell RNA-seq datasets, orthotopic glioma models, primary CD8+ T cell co-culture systems, and tandem mass tag proteomics to find that CD81 was highly expressed in radioresistant GBM and governed GBM immune evasion.